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Interferon Alpha-2 Monoclonal Mouse Antibody (N39)

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Product Attributes

Antibody number

#0298

Antibody reactivity (target)

Interferon Alpha-2

Antibody type

Primary

Host species

Mouse

Clonality

Monoclonal

Clone

N39

Isotype

IgG1, kappa

Molecular weight

16-27 kDa

Synonyms

Alpha 2a interferon; IFN alpha; IFN-alpha-2; IFNA; IFNA2; IFNA2B; Interferon alpha 2a; Interferon alpha 2b; Interferon alpha-2; Interferon alpha-A; LeIF2; LeIFA

Human gene symbol

IFNA2

Entrez gene ID

3440

SwissProt

P01563

Unigene

211575

Immunogen

Purified recombinant human IFN-alpha2

Antibody target cellular localization

Secreted (extracellular)

Species reactivity

Human

Antibody application notes

For coating for ELISA, order Ab without BSA, Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody, Optimal dilution and staining procedure for a specific application should be determined by user, Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry

Positive control

Stimulated human peripheral blood mononuclear cells

Shipping condition

Room temperature

Storage Conditions

Store at 2 to 8 °C, Protect fluorescent conjugates from light, Note: store BSA-free antibodies at -10 to -35 °C

Regulatory status

For research use only (RUO)

Antibody/conjugate formulation

Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA, Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide

Shelf life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Cell/tissue expression

Lymphocytes, Monocytes/macrophages

Antibody research areas

Cytokines, Immunology, Inflammation

Conjugation
Don’t see what you’re looking for? Contact us for more conjugation options.
Note: Please be advised that primary antibodies with catalog numbers that begin with “BN” will only be offered conjugated to CF®405S, CF®488A, CF®568, CF®594, CF®640R, CF®647, and biotin as of 5/27/2022. However, previously available primary antibody conjugates that are in stock will remain available until inventory is exhausted. Please view the list of available conjugates on the product page. We also recommend our easy-to-use Mix-n-StainTM Antibody Labeling Kits for labeling antibodies with all CF® Dyes. We apologize for the inconvenience.
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Product Description

This antibody recognizes a protein of 16-27 kDa, identified as human interferon-alpha-2 (IFN-a2). Its epitope maps between aa112-148 of IFN-a2 (total aa172). This MAb is specific for IFN-a2 and does not cross-react with interferon-alpha-1. The site recognized by this MAb is called site I and is responsible for the antiviral and anti-proliferative activities of IFN-a2. Epitopes of N27 and N39 MAbs are different and represent a good combination of antibodies to set up an ELISA assay for the quantitation of IFN-a2 after viral infections. The IFN-a family consists of 24 or more genes or pseudo-genes. IFN-a2 is one of the two distinct families (I and II) of human IFN-a. The alpha-interferons are mainly produced by lymphocytes, monocytes, macrophages, and cell lines such as Namalwa and KG1 following induction by viruses, nucleic acids, and glucocorticoid hormones. They are involved in virus resistance on target cells, inhibition of cell proliferation, induction of cytokines and regulation of expression of MHC class I antigens.

 

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