Monoclonal anti LEC Chemokine (LEC67)

BNUB0067-0
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Product Description

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelo-suppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones. The ability of HCC-4 to markedly improve recognition of poorly immunogenic cells suggests that it could be an effective component of antitumor vaccines.

Hedrick, J.A., Helms, A., Vicari, A. and Zlotnik, A. 1998. Characterization of a novel C-C chemokine, HCC-4, whose expression is increased by inter- leukin-10. Blood 91: 4242-4247

Additional Information

Conjugation

Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP

Size

50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type

Primary

Host species

Mouse

Reactivity (target)

LEC Chemokine (LEC67)

Clonality

Monoclonal

Clone

LEC67

Isotype

IgG1, kappa

Molecular weight

11 kDa

Synonyms
Entrez gene ID

6360

SwissProt

O15467

Immunogen

Recombinant human HCC-4 protein

Unigene

10458

Species reactivity

Human

Applications

ELISA

Cellular localization

Secreted (extracellular)

Application notes

ELISA For coating, order Ab without BSA Optimal dilution for a specific application should be determined by user

Positive control

Liver, spleen and thymus

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

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