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Reactive DNA/RNA Binding Dyes

Amine reactive succinimidyl ester (SE) of nucleic acid dyes can be conjugated to proteins or other molecules with primary amine groups. The conjugates should be essentially nonfluorescent until they bind DNA or RNA, resulting in fluorescence. We also offer reactive methylene blue, a colorimetric DNA/RNA stain.

PMA, PMAxx™, and EMA are nucleic acid binding dyes that covalently react with DNA and RNA after photoactivation. They are useful for PCR-based quantitation of microbial viability (learn more about viability PCR).

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    AO Succinimidyl Ester

    From: $329 Sizes: 5 mgCatalog #: 40074

    The amine reactive succinimidyl ester of AO (acridine orange) can be conjugated to peptides, proteins, drugs, polymeric materials and biomolecules with primary amine groups.  The conjugates with green fluoroscence are able to complex with nucleic acids, resulting in green fluorescence nucleic acid conjugate adduct.

     
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    EB Succinimidyl Ester

    From: $329 Sizes: 5 mgCatalog #: 40072

    The amine reactive succinimidyl ester of EB (ethidium bromide) can be conjugated to peptides, proteins, drugs, polymeric materials and biomolecules with primary amine groups.  The conjugates are expected to be essentially nonfluorescent until they are able to complex with nucleic acids, resulting in red fluorescence.

     
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    MB Succinimidyl Ester

    From: $329 Sizes: 5 mgCatalog #: 40075

    The amine reactive succinimidyl ester of MB (methylene blue) can be conjugated to peptides, proteins, drugs, polymeric materials and biomolecules with primary amine groups.  The conjugate will have a blue color and be able to complex with nucleic acids.

     
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    MB-Azide

    From: $261 Sizes: 1 mgCatalog #: 40117

    A commonly used redox indicator in nucleic acid research. MB-Azide can be used to label alkyne, BCN, or phosphine-containing molecules.

     
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    MB-DBCO

    From: $261 Sizes: 1 mgCatalog #: 40114

    A commonly used redox indicator in nucleic acid research. MB-dibenzocyclooctyne (DBCO) allows copper-free bioorthogonal conjugation to spontaneously label molecules containing azide groups.

     
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    MB-Maleimide

    From: $261 Sizes: 1 mgCatalog #: 40118

    A commonly used redox indicator in nucleic acid research. MB-Maleimide can be used to label molecules containing free thiol groups.

     
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    MB-Methyltetrazine

    From: $261 Sizes: 1 mgCatalog #: 40115

    A commonly used redox indicator in nucleic acid research. MB-methyltetrazine may be used to label TCO (trans-cyclooctene) tagged molecules via a copper-free reaction.

     
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    MB-TCO

    From: $261 Sizes: 1 mgCatalog #: 40116

    A commonly used redox indicator in nucleic acid research. MB-TCO (trans-cyclooctene) may be used to label tetrazine tagged molecules via a copper-free reaction.

     
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    TO Succinimidyl Ester

    From: $329 Sizes: 5 mgCatalog #: 40073

    The amine reactive succinimidyl ester of TO (thiazole orange) can be conjugated to peptides, proteins, drugs, polymeric materials and biomolecules with primary amine groups.  The conjugates are expected to be essentially nonfluorescent until they are able to complex with nucleic acids, resulting in green fluorescence.

     
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    PMAxx™ Dye, 20 mM in H2O

    From: $159 Sizes: 100 uLCatalog #: 40069

    Viability PCR dye, a new and improved version of the popular viability dye propidium monoazide (PMA).

     
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    PMA (Propidium Monoazide)

    From: $167 Sizes: 100 uL, 1 mgCatalog #:
    40013
    , - 40019View allHide

    A photo-reactive DNA-binding dye typically used in viability PCR (v-PCR) of microorganisms like bacteria, viruses, and fungi.

     
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    Ethidium Monoazide Bromide (EMA)

    From: $210 Sizes: 5 mgCatalog #: 40015

    A photo-activated fluorescent nucleic acid binding dye used to selectively and covalently label dead cells in the presence of live cells for viability PCR, fluorescent microscopy, and flow cytometry.