Receptor/Ion Channel Toxins & Probes
Fluorescently-labeled toxins can be used to label or inhibit receptors or ion channels on neurons. Biotium offers these labeled with a variety of bright, stable CF® Dyes. α-Bungarotoxin binds to the acetylcholine receptor. Cholera Toxin B binds to GM1 gangliosides in lipid rafts. Tetrodotoxin reversibly blocks excitable sodium channels.
Biotium also offers other fluorescently-labeled molecules to bind to cell surface receptors. Transferrin binds to its receptor and is internalized by endocytosis. cAMP can be used to probe cAMP receptors.