Receptor/Ion Channel Toxins & Probes
Fluorescently-labeled toxins can be used to label or inhibit receptors or ion channels on neurons. Biotium offers these labeled with a variety of bright, stable CF® Dyes. α-Bungarotoxin binds to the acetylcholine receptor. Cholera Toxin B binds to GM1 gangliosides in lipid rafts. Tetrodotoxin reversibly blocks excitable sodium channels.
Biotium also offers other fluorescently-labeled molecules to bind to cell surface receptors. Transferrin binds to its receptor and is internalized by endocytosis. cAMP can be used to probe cAMP receptors.
α-Bungarotoxin, CF® Dye and Other Conjugates
00026-100ug, 00002, 00003, 00004, 00005, 00006, 00007, 00009, 00011, 00012, 00013, 00014, 00015, 00016, 00018, 00026, 00003-100ug, 00004-100ug, 00005-100ug, 00006-100ug, 00007-100ug, 00009-100ug, 00018-100ug, - 00002-100ugView allHide
Conjugates of α-Bungarotoxin labeled with a selection of our CF® Dyes and other labels. Labeled α-bungarotoxin conjugates can be used for staining nicotinic acetylcholine receptors at neuromuscular junctions in tissue sections.
CF® Dye cAMP
00036, - 00037View allHide
Fluorescently labeled cAMP analogs that can be used to probe cAMP receptors.
Cholera Toxin Subunit B CF® Dye Conjugates
00068, 00070, 00071, 00072, 00073, 00074, 00075, 00077, 00069, 00078, - 00079View allHide
Binds GM1 ganglioside in lipid rafts and is used as a retrograde neuronal tracer for live imaging or on fixed cells.
Transferrin (human) CF® Dye Conjugates
00081, 00082, 00083, 00084, 00085, 00086, - 00087View allHide
Labeled human transferrin is used for microscopic studies of the endosomal pathway and/or transferrin uptake studies.
α-Bungarotoxin
A high affinity inhibitor of the nicotinic acetylcholine receptor in the neuromuscular junction. Blocks acetylcholine activity at the postsynaptic membrane.
Biotin-cAMP
00020, - 00020-1View allHide
A biotin-conjugated cAMP analog that can be used to probe cAMP receptors.
Biotin-cGMP, Diisopropylethylammonium Salt
00021, - 00021-1View allHide
A biotinylated cyclic nucleotide that is an important second messenger in many biological processes and has been used as a tracer in immunoassays.
Biotin-XX-α-Bungarotoxin
A high affinity inhibitor of the nicotinic acetylcholine receptor in the neuromuscular junction. Blocks acetylcholine activity at the postsynaptic membrane. The biotin conjugate can be subsequently labeled with anti-biotin antibodies, avidin, or streptavidin for signal amplification.
Cyanine 644-cAMP
00022, - 00022-1View allHide
A fluorescently labeled cAMP analog that can be used to probe cAMP receptors.
Tetrodotoxin
00060, - 00061View allHide
This toxin reversibly blocks the sodium channels of neurons and has been a widely used tool for mechanistic studies of neurons, skeletal muscle, and cardiac muscle cells.