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Thiol-Reactive Dyes

Maleimide reacts with thiol groups to form thioether-coupled products. The reaction can take place at pH 7 in the presence of amines. At neutral pH, the maleimide group does not react with histidine or arginine. Maleimide labeling can be a useful alternative to succinimidyl ester labeling in cases where modification of lysines alters antibody binding affinity or other biological activity of the target protein. We offer more than 20 bright and photostable CF® Dye Maleimides.

Methanethiosulfonate (MTS) is a fast-reacting and highly selective thiol-reactive functional group. We offer CF® Dye MTS with a selection of popular colors. We also offer MTS thiol-modifying and cross-linking agents.

We also offer many classic thiol-reactive dyes and biotin, as well as reducing agents commonly used in thiol conjugation protocols.

Showing 1–16 of 45 results

    MTS-BCN

    From: $360 Sizes: 1 mgCatalog #: 96023

    BCN, an alternative to DIBO and DBCO, reacts with azide to form 1,2,3-triazole by copper free 1,3-dipolar Huisgen cycloaddition. MTS-BCN is a fast-reacting and highly selective thiol-reactive label that permits one to attach BCN to a thiol group.

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    BCN, an alternative to DIBO and DBCO, reacts with azide to form 1,2,3-triazole by copper free 1,3-dipolar Huisgen cycloaddition. MTS-BCN is a fast-reacting and highly selective thiol-reactive label that permits one to attach BCN to a thiol group.

     

    CPMTS

    From: $79 Sizes: 5 mgCatalog #: 91011

    Biotium developed CPMTS as an alternative to the widely used thiol-reactive coumarin dye CPM (#91010).

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    Biotium developed CPMTS as an alternative to the widely used thiol-reactive coumarin dye CPM (#91010).

     

    ROX maleimide, 5 and 6 isomers

    From: $152 Sizes: 5 mgCatalog #: 91055

    5(6)-ROX maleimide has C6-linker that enhances the fluorescence after the dye is conjugated to proteins. The product is a direct replacement of 5(6)-carboxy-X-rhodamine C5-maleimide (91041).

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    5(6)-ROX maleimide has C6-linker that enhances the fluorescence after the dye is conjugated to proteins. The product is a direct replacement of 5(6)-carboxy-X-rhodamine C5-maleimide (91041).

     

    TAMRA-C5-maleimide, 5 and 6 isomers

    Sizes: Catalog #:

    This product has been discontinued and replaced by 5(6)-ROX maleimide (#91055).

    This product is currently out of stock and unavailable.

    This product has been discontinued and replaced by 5(6)-ROX maleimide (#91055).

     

    N-(1,10-Phenanthrolin-5-yl)iodoacetamide

    From: $107 Sizes: 5 mgCatalog #: 92015

    N-(1,10-Phenanthrolin-5-yl)iodoacetamide has been used to label thiols to confer the metal-binding properties of the phenanthroline chelator. For example, completing of the chelator with copper can be used to selectively cleave RNA or DNA in the presence of hydrogen peroxide.

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    N-(1,10-Phenanthrolin-5-yl)iodoacetamide has been used to label thiols to confer the metal-binding properties of the phenanthroline chelator. For example, completing of the chelator with copper can be used to selectively cleave RNA or DNA in the presence of hydrogen peroxide.

     

    Sulforhodamine 101 (Texas Red) C5-maleimide

    From: $208 Sizes: 5 mgCatalog #: 92014

    Sulforhodamine 101 C5-maleimide is a long wavelength fluorescent thiol-reactive dye.

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    Sulforhodamine 101 C5-maleimide is a long wavelength fluorescent thiol-reactive dye.

     

    Tetramethylrhodamine maleimide, 5 and 6 isomers

    From: $150 Sizes: 5 mgCatalog #: 91054

    5(6)-Carboxytetramethylrhodamine maleimide has C6-linker that enhances the fluorescence after the dye is conjugated to proteins. The product is a direct replacement for 5(6)-carboxytetramethylrhodamine C5-maleimide (91040).

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    5(6)-Carboxytetramethylrhodamine maleimide has C6-linker that enhances the fluorescence after the dye is conjugated to proteins. The product is a direct replacement for 5(6)-carboxytetramethylrhodamine C5-maleimide (91040).

     

    MTS-5-TAMRA

    From: $71 Sizes: 1 mgCatalog #: 91053

    MTS-5-TAMRA (5-carboxytetramethylrhodamine methanethiosulfonate) is a fast-reacting and highly selective thiol-reactive label that permits one to attach the popular fluorescent dye TAMRA to a thiol group.

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    MTS-5-TAMRA (5-carboxytetramethylrhodamine methanethiosulfonate) is a fast-reacting and highly selective thiol-reactive label that permits one to attach the popular fluorescent dye TAMRA to a thiol group.

     

    MTS-6-TAMRA

    From: $71 Sizes: 1 mgCatalog #: 91052

    MTS-6-TAMRA (6-carboxytetramethylrhodamine methanethiosulfonate) is a fast-reacting and highly selective thiol-reactive label that permits one to attach the popular fluorescent dye TAMRA to a thiol group.

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    MTS-6-TAMRA (6-carboxytetramethylrhodamine methanethiosulfonate) is a fast-reacting and highly selective thiol-reactive label that permits one to attach the popular fluorescent dye TAMRA to a thiol group.

     

    N-(6-Aminohexyl)maleimide, trifluoroacetic acid salt

    From: $386 Sizes: 100 mgCatalog #: 91051

    N-(6-Aminohexyl)maleimide is a cross-linking reagent that can react with an amine-reactive group and a thiol group.

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    N-(6-Aminohexyl)maleimide is a cross-linking reagent that can react with an amine-reactive group and a thiol group.

     

    DTT

    From: $32 Sizes: 1 gCatalog #: 91050

    DTT

    DTT (dithiothreitol) is a reducing agent commonly used to reduce cystine disulfides to free thiols.

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    DTT (dithiothreitol) is a reducing agent commonly used to reduce cystine disulfides to free thiols.

     

    TCEP

    From: $69 Sizes: 1 gCatalog #: 91049

    TCEP hydrochloride is an odorless reducing agent that is more stable and effective than dithiothreitol (DTT) or 2-Mercaptoethanol. TCEP hydrochloride is soluble in water to 310 grams per liter.

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    TCEP hydrochloride is an odorless reducing agent that is more stable and effective than dithiothreitol (DTT) or 2-Mercaptoethanol. TCEP hydrochloride is soluble in water to 310 grams per liter.

     

    MTS-Sulforhodamine 101 (Texas Red)

    From: $175 Sizes: 5 mgCatalog #: 91048

    MTS-sulforhodamine 101 is a fast-reacting and highly selective thiol-reactive rhodamine dye.

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    MTS-sulforhodamine 101 is a fast-reacting and highly selective thiol-reactive rhodamine dye.

     

    ABD-F

    From: $74 Sizes: 10 mgCatalog #: 91046

    ABD-F is a useful reagent for the sensitive and specific detection of thiols both by TLC and HPLC (1,2). When combined with a reducing agent such as tributylphosphine, it can also be used for the determination of disulfides in peptides and proteins (3,4).

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    10 mg
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    ABD-F is a useful reagent for the sensitive and specific detection of thiols both by TLC and HPLC (1,2). When combined with a reducing agent such as tributylphosphine, it can also be used for the determination of disulfides in peptides and proteins (3,4).

     

    BisEA

    From: $116 Sizes: 50 mgCatalog #: 91045

    BisEA (Bis-(2-(Methanethiosulfonato)ethyl)amine, hydrochloride) is a positively charged MTS cross-linker.

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    BisEA (Bis-(2-(Methanethiosulfonato)ethyl)amine, hydrochloride) is a positively charged MTS cross-linker.

     

    3,6,9,12-Tetraoxatetradecane-1,14-diyl dimethanethiosulfonate

    From: $91 Sizes: 10 mgCatalog #: 91044

    3,6,9,12-Tetraoxatetradecane-1,14-diyl dimethanethiosulfonate is a water soluble MTS cross-linker.

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    3,6,9,12-Tetraoxatetradecane-1,14-diyl dimethanethiosulfonate is a water soluble MTS cross-linker.