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MB-TCO

A commonly used redox indicator in nucleic acid research. MB-TCO (trans-cyclooctene) may be used to label tetrazine tagged molecules via a copper-free reaction.

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Product Description

Methylene Blue (MB) is a commonly used redox indicator in nucleic acid research. It is also studied for its use in medical applications as well as being used as a general biological stain. Reactive formats of MB can be conjugated to biomolecules.  The conjugate will have a blue color and be able to complex with nucleic acids.

MB-TCO (trans-cyclooctene) is a reactive form of MB that may be used to label tetrazine tagged molecules via a copper-free reaction. We also offer MB Acid and a selection of other chemically reactive formats for use in labeling biomolecules such as proteins and nucleic acids.

  • MW: ~650
  • Store at -20°C and protected from light

See the table below for our full list of metheylene blue derivatives and formats.

Methylene Blue Derivatives

ProductSizeCatalog No.Features
MB Acid5 mg40076Free acid form
MB Succinimidyl Ester5 mg40075Amine-reactive chemistry for labeling proteins
MB-Maleimide1 mg40118Thiol-reactive chemistry for labeling proteins
MB-DBCO1 mg40114Allows bioorthogonal conjugation to label azide containing molecules
MB-Methyltetrazine1 mg40115Allows labeling of TCO tagged molecules
MB-TCO1 mg40116Allows labeling of tetrazine tagged molecules
MB-Azide1 mg40117Allows labeling alkyne, BCN, or phosphine-containing molecules.

See our other reactive DNA/RNA binding dyes.

 

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    MB Acid

    MB (methylene blue) acid can be conjugated to peptides, proteins, drugs, polymeric materials and biomolecules with primary amine groups.  The conjugate will have a blue color and be able to complex with nucleic acids.

    MB Succinimidyl Ester

    The amine reactive succinimidyl ester of MB (methylene blue) can be conjugated to peptides, proteins, drugs, polymeric materials and biomolecules with primary amine groups.  The conjugate will have a blue color and be able to complex with nucleic acids.

    MB-Azide

    A commonly used redox indicator in nucleic acid research. MB-Azide can be used to label alkyne, BCN, or phosphine-containing molecules.

    MB-DBCO

    A commonly used redox indicator in nucleic acid research. MB-dibenzocyclooctyne (DBCO) allows copper-free bioorthogonal conjugation to spontaneously label molecules containing azide groups.

    MB-Maleimide

    A commonly used redox indicator in nucleic acid research. MB-Maleimide can be used to label molecules containing free thiol groups.

    MB-Methyltetrazine

    A commonly used redox indicator in nucleic acid research. MB-methyltetrazine may be used to label TCO (trans-cyclooctene) tagged molecules via a copper-free reaction.