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TCEP

TCEP hydrochloride is an odorless reducing agent that is more stable and effective than dithiothreitol (DTT) or 2-Mercaptoethanol. TCEP hydrochloride is soluble in water to 310 grams per liter.

Product Attributes

CAS number

51805-45-9

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Product Description

TCEP (Tris(2-carboxyethyl)phosphine) hydrochloride is an odorless reducing agent that is more stable and effective than dithiothreitol (DTT) or 2-Mercaptoethanol. TCEP hydrochloride is soluble in water to 310 grams per liter. Unlike DTT, TCEP hydrochloride retains its reducing power at acid pH (pH 5) and at pH above 7.5. TCEP hydrochloride is unreactive towards other functional groups found in proteins. For reducing disulfide bonds in peptides or proteins, 5-50 mM TCEP can be used for a few minutes at room temperature.

Molecular Information

  • C9H15O6P HCl
  • Mwt: 286.64
  • [51805-45-9]

References

1. Anal Biochem 180, 231-236 (1989).

2. Anal Biochem 220, 5-10 (1994).

3. Nature Biotech 19, 379-382 (2001).

 

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