Come Join Our Team!
Biotium is a leading life science reagent manufacturer and supplier devoted to providing high-quality and innovative fluorescent tools that fuel scientific discovery. Our collaborative team of experienced chemists and biologists, who are at the forefront of fluorescent dye design, apply chemistry-based principles toward producing solutions for unmet challenges in life science and medical research. Since its founding in 2001, Biotium has developed over 30 patented technologies including GelRed® dyes, CF® Dyes, NucView® Caspase-3 Substrates, EvaGreen® Dyes, and TrueBlack® Background Reducers. Many of these technologies have been licensed out to leading life science technology companies worldwide.
See our current career opportunities below:
- Staff Scientist (Chemistry)
- Chemistry Technician I (Chemistry)
- Bioconjugation Scientist (Bioconjugation)
Staff Scientist (Chemistry)
JOB TITLE: Staff Scientist (Chemistry)
LOCATION: Fremont, California
JOB FUNCTIONS:
This Staff Scientist (Chemistry) position focuses on the production of fluorescent reagents and improvement of manufacturing processes. This position will also involve developing novel fluorescent reagents for various detection platforms such as flow cytometry, microscopy, and live cell imaging systems.
JOB OBJECTIVE:
Under direct supervision from the VP of Research and Development, the Staff Scientist will perform R&D and production projects to synthesize organic fluorescent dyes and related compounds utilizing/modifying existing protocols. The Staff Scientist will also design and execute new protocols for custom orders and new production items. The Staff Scientist will be expected to use his/her extensive knowledge of chemistry to successfully complete complex multi-step reactions.
ESSENTIAL DUTIES:
- Under general guidelines, independently plan, organize, and perform the synthesis of new and existing products to meet product specifications. Plans production schedule for on-time delivery of products
- Write, review and revise, as necessary, manufacturing and QC protocols for clarity, process improvement and/or material changes as prescribed by procedures and policies
- Independently adapt or modify methods to achieve technical objectives
- Address and report problems in daily production and propose effective countermeasures
- Proactively identify areas for improvement and drive efficiency results
- Use highly specialized equipment and instrumentation in daily functions
- Critically analyze data and interpret experimental results
- Write protocols and lab notebooks documenting processes and improvements consistent with ISO 9001 standards
- Work as an active team member assisting the implementation of new processes within the production group
- Maintain a high level of professional expertise through familiarity with current scientific literature with respect to compounds, reactions, and processes
- Maintain a safe and clean work environment
MANDATORY QUALIFICATIONS:
- Demonstrated competence in reaction design, process improvement, and product purification
- Depth of synthetic experience from milligram to kilogram scale
- Excellent time management skills and ability to work independently
- Proven ability to lead and provide work direction
- Careful, precise and accurate laboratory techniques
- Proficiency in the analysis and interpretation of technical and laboratory data
- Ability to effectively organize tasks, data and documentation
- Skilled in problem solving and diagnostic troubleshooting
- Proficiency in the maintenance of accurate records involving production, analysis, and the documentation of results
- Verbal and written communication skills, and ability to express scientific results clearly and concisely
- Ability to complete multiple tasks quickly and efficiently
- Ability to master new skills, methods, and instrumentation quickly
- Ability to work independently and as a team player, and to follow supervisory direction
JOB CONDITIONS:
Work is carried out in a typical chemistry laboratory setting. Work may require frequent sitting, standing, walking, lifting, and/or carrying of chemicals or chemical containers. Work may also require sitting and working at a computer or standing at a laboratory bench for long periods of time.
EDUCATION REQUIREMENTS:
Ph.D degree in Chemistry, or other related discipline, or the equivalent knowledge and experience is required.
COMPENSATION AND BENEFITS:
Salary depending on experience/education. Standard company-paid benefits (health insurance, 401k matching, sick, vacation and holiday)
TO APPLY:
Email your resume and cover letter to chemjob@biotium.com.
Chemistry Technician I (Chemistry)
JOB TITLE: Chemistry Technician I
LOCATION: Fremont, California
JOB OBJECTIVE:
Under the direct supervision from a senior chemist, perform chemical purifications using chromatography including preparative HPLC or gravity chromatography; carry out chemical synthesis using standard protocols; carry out chemical analyses using modern instruments including analytical HPLC, LC-MS, TLC, UV/Vis and fluorescence spectrophotometry.
ESSENTIAL DUTIES:
- Perform purifications of chemical compounds by preparative HPLC or gravity chromatography
- Perform production of chemical compounds by following ISO protocols
- Perform analytical HPLC on compounds
- Must possess sufficient chemistry knowledge and HPLC experiences to develop HPLC conditions for both analytical and preparative purposes using chemical structure information provided
- Perform LC-MS on chemical compounds and interpret the results
- Perform UV/Vis and/or fluorescence spectrophotometry on dyes
- Responsible for the maintenance and minor repair of the above instruments
- Write protocols for laboratory procedures and accurately and clearly document results and observations in lab notebooks
- Work as an active team member assisting the implementation of new processes within the chemistry group and the company
- Maintain high level of professional expertise through familiarity with current scientific literature with respect to compounds, reactions, and processes
- Maintain a safe and clean work environment
MANDATORY QUALIFICATIONS:
- Demonstrated competence in analytical and preparative HPLC
- Excellent time management skills and ability to work independently required
- Careful, precise and accurate laboratory techniques
- Proficiency in the analysis and interpretation of technical and laboratory data
- Ability to effectively organize tasks, data and documentation
- Skilled in problem solving and diagnostic troubleshooting
- Proficiency in the maintenance of accurate records involving production and analysis and the documentation of results
- Verbal and written communication skills and ability to express scientific results clearly and concisely
- Ability to complete multiple tasks quickly and efficiently
- Ability to master new skills, methods and instrumentation quickly
- Ability to work independently and as a team player, and to follow supervisory direction
EDUCATION REQUIREMENTS:
B.S. or M.S. degree in Chemistry or the equivalent knowledge and experience is required.
JOB CONDITIONS:
Work is carried out in a typical chemistry laboratory setting. Work may require frequent sitting, standing, walking and lifting and/or carrying of chemicals or chemical containers. Work may also require sitting and working at a computer or standing at a laboratory bench for long periods of time.
COMPENSATION AND BENEFITS:
Salary dependent on experience/education. Company-paid benefits include: medical, dental, and vision insurance coverage, 401K, sick leave, vacation, and company holidays.
Job Type: Full-time
TO APPLY:
Email your resume and cover letter to chemjob@biotium.com.
Bioconjugation Scientist (Bioconjugation)
JOB TITLE: Bioconjugation Scientist (Bioconjugation)
LOCATION: Fremont, CA
JOB OBJECTIVE:
Under direct supervision from the VP of Research and Development, perform synthesis, purification, and characterization of antibody/biomolecule conjugates of fluorescent dyes, fluorescent proteins, tandem dyes, enzyme reporters, and polymeric scaffolds. Research and development leading to commercialization of bioconjugates for research applications. The successful candidate will possess a strong background in chemistry and bioconjugation chemistry and have experience performing bioconjugation reactions, protein purification, and requisite analytical techniques.
ESSENTIAL DUTIES:
- Synthesize bioconjugates using established chemistries
- Contribute to the development of new bioconjugation methodologies
- Evaluate new bioconjugation methods from the literatures
- Purify bioconjugates by size exclusion chromatography, ion-exchange chromatography, affinity chromatography and hydrophobic interaction chromatography
- Optimize protein and antibody conjugation and purification methods
- Develop and implement assays for quality control
- Create SOPs and transfer to manufacturing
- Provide technical support and troubleshooting to manufacturing
- Working knowledge of AKTA platform or equivalents
- Characterize bioconjugates using multiple techniques such as UV/Vis, fluorescence, HPLC, MS and particle analyzer
- Mentor research associates in experimental design, data interpretation, laboratory and instrument techniques and best practices
- Operates lab instruments according to established procedures and prepares reagents as needed
- Critically analyzes, summarizes, and reports data generated from experiments, draws conclusions from experimental results and recommends and executes required follow-up actions with consideration of prior experimental findings (self and others) with minimal supervision
- Presents data at team meetings or to small focus groups that may include representatives from other departments and/or outside parties and participates in brainstorming and troubleshooting sessions within or between teams, offering and implementing solutions to problems
- Performs and is involved in the planning and documentation of verification activities to ensure that newly developed products meet the pre-determined product specifications
- May facilitate the transfer research products to Manufacturing/Operations and is involved in completion and release of enabling documentation for newly developed products by ensuring all relevant technical information is incorporated into the appropriate documents
- Maintains familiarity with current technology related information and/or literature and conducts project related information searches and may be involved in extensive literature searches
- Trains others in laboratory procedures and processes, and in the design, execution, and analysis of experiments. Provides feedback to supervisor on training progress
- Performs other duties and assumes additional departmental responsibilities as required. Performs other assignments and tasks as directed
- Demonstrates excellent written and verbal communication skills within and between departments. Maintains appropriate laboratory records, notebooks, and other formal company documentation, as required
- Works under minimal supervision, receiving no instructions on routine work, general instructions on new assignments, and detailed instructions or training on new applications or responsibilities
- Works on complex problems where analysis of situations or data requires an in-depth evaluation of various factors, and exercises judgment within broadly defined practices and policies to determine appropriate conclusion and follow up action
MANDATORY QUALIFICATIONS:
PhD degree in Chemistry or Biological Science with 3 year experience in bioconjugation or MS/B Sc degree in Chemistry or Biological Science with 7 year experience in bioconjugation.
PREFERRED QUALIFICATIONS:
- Solid knowledge in chemistry, biochemistry and fluorescent dye chemistry
- Strong analytical methods such as chromatography, spectrophotometry, gel electrophoresis and particle analyzer
- An independent self-starter who enjoys problem solving and diagnostic troubleshooting
- Excellent time management skills and ability to complete multiple tasks quickly and efficiently in a flexible and fast-paced research environment
- Careful, precise and accurate laboratory techniques
- Ability to effectively organize tasks, maintain accurate records and documentation of results
- Ability to master new skills, methods and instrumentation quickly
- Ability to work independently and as a team player, and to follow supervisory direction
- Excellent verbal and writing skills for internal and customer-facing communication
JOB CONDITIONS:
Work is carried out in a typical biology laboratory setting. Work may require frequent sitting, standing, walking and lifting and/or carrying of chemicals or chemical containers. Work may also require sitting and working at a computer or standing at a laboratory bench for long periods of time.
COMPENSATION AND BENEFITS:
Salary dependent on experience/education. Company-paid benefits include: medical, dental, and vision insurance coverage, 401K, sick leave, vacation, and company holidays.
TO APPLY:
Email your resume and cover letter to chemjob@biotium.com.