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Innovative dyes for science. Expert solutions for scientists.

Biotium is a leading life science reagent manufacturer and supplier devoted to providing high-quality and innovative fluorescent tools that fuel scientific discovery. Our collaborative team of experienced chemists and biologists, who are at the forefront of fluorescent dye design, apply chemistry-based principles toward producing solutions for unmet challenges in life science and medical research. Since its founding in 2001, Biotium has developed over 30 patented technologies including GelRed® dyes, CF® dyes, NucView® Caspase-3 Substrates, EvaGreen® dyes, and TrueBlack® Background Reducers. Many of these technologies have been licensed out to leading life science technology companies worldwide.

See our current job openings below for opportunities to join our team.

Staff Scientist (Chemistry)

JOB TITLE: Staff Scientist (Chemistry)

LOCATION: Fremont, California

DATE EFFECTIVE: 01/08/2020

JOB FUNCTIONS:

This Staff Scientist (Chemistry) position focuses on the production of fluorescent reagents and improvement of manufacturing processes. This position will also involve developing novel fluorescent reagents for various detection platforms such as flow cytometry, microscopy, and live cell imaging systems.

JOB OBJECTIVE:

Under direct supervision from the VP of Research and Development, the Staff Scientist will perform R&D and production projects utilizing/modifying existing protocols. The Staff Scientist will also design and execute new protocols for custom orders and new production items. The Staff Scientist will be expected to use his/her extensive knowledge of chemistry to successfully complete complex multi-step reactions.

ESSENTIAL DUTIES:

  • Under general guidelines, independently plan, organize, and perform the synthesis of new and existing products to meet product specifications. Plans production schedule for on-time delivery of products.
  • Write, review and revise, as necessary, manufacturing and QC protocols for clarity, process improvement and/or material changes as prescribed by procedures and policies.
  • Independently adapt or modify methods to achieve technical objectives.
  • Address and report problems in daily production and propose effective countermeasures.
  • Proactively identify areas for improvement and drive efficiency results.
  • Use highly specialized equipment and instrumentation in daily functions.
  • Critically analyze data and interpret experimental results.
  • Write protocols and lab notebooks documenting processes and improvements consistent with ISO 9001 standards.
  • Work as an active team member assisting the implementation of new processes within the production group.
  • Maintain a high level of professional expertise through familiarity with current scientific literature with respect to compounds, reactions, and processes.
  • Maintain a safe and clean work environment.

MANDATORY QUALIFICATIONS:

  • Demonstrated competence in reaction design, process improvement, and product purification.
  • Depth of synthetic experience from milligram to kilogram scale
  • Excellent time management skills and ability to work independently
  • Proven ability to lead and provide work direction..
  • Careful, precise and accurate laboratory techniques.
  • Proficiency in the analysis and interpretation of technical and laboratory data.
  • Ability to effectively organize tasks, data and documentation.
  • Skilled in problem solving and diagnostic troubleshooting.
  • Proficiency in the maintenance of accurate records involving production,analysis,and the documentation of results.
  • Verbal and written communication skills, and ability to express scientific results clearly and concisely.
  • Ability to complete multiple tasks quickly and efficiently.
  • Ability to master new skills, methods, and instrumentation quickly.
  • Ability to work independently and as a team player, and to follow supervisory direction.

JOB CONDITIONS:

Work is carried out in a typical chemistry laboratory setting. Work may require frequent sitting, standing, walking, lifting, and/or carrying of chemicals or chemical containers. Work may also require sitting and working at a computer or standing at a laboratory bench for long periods of time.

EDUCATION REQUIREMENTS:

Ph.D degree in Chemistry, or other related discipline, or the equivalent knowledge and experience is required.

COMPENSATION AND BENEFITS:

Salary depending on experience/education. Standard company-paid benefits (health insurance, 401k matching, sick, vacation and holiday)

TO APPLY:

Email your resume and cover letter to chemjob@biotium.com.

Chemistry Technician I (Chemistry)

JOB TITLE: Chemistry Technician I

LOCATION: Fremont, California

DATE EFFECTIVE: 06/01/2019

JOB OBJECTIVE:

Under the direct supervision from senior chemist, perform chemical purifications using chromatography including preparative HPLC or gravity chromatography; carry out chemical synthesis using standard protocols; carry out chemical analyses using modern instruments including analytical HPLC, LC-MS, TLC, UV/Vis and fluorescence spectrophotometry.

ESSENTIAL DUTIES:

  • Perform purifications of chemical compounds by preparative HPLC or gravity chromatography.
  • Perform production of chemical compounds by following ISO protocols
  • Perform analytical HPLC on compounds.
  • Must possess sufficient chemistry knowledge and HPLC experiences to develop HPLC conditions for both analytical and preparative purposes using chemical structure information provided.
  • Perform LC-MS on chemical compounds and interpret the results.
  • Perform UV/Vis and/or fluorescence spectrophotometry on dyes.
  • Responsible for the maintenance and minor repair of the above instruments.
  • Write protocols for laboratory procedures and accurately and clearly document results and observations in lab notebooks.
  • Work as an active team member assisting the implementation of new processes within the chemistry group and the company.
  • Maintain high level of professional expertise through familiarity with current scientific literature with respect to compounds, reactions, and processes.
  • Maintain a safe and clean work environment.

 MANDATORY QUALIFICATIONS:

  • Demonstrated competence in analytical and preparative HPLC.
  • Excellent time management skills and ability to work independently required.
  • Careful, precise and accurate laboratory techniques.
  • Proficiency in the analysis and interpretation of technical and laboratory data.
  • Ability to effectively organize tasks, data and documentation.
  • Skilled in problem solving and diagnostic troubleshooting.
  • Proficiency in the maintenance of accurate records involving production and analysis and the documentation of results.
  • Verbal and written communication skills and ability to express scientific results clearly and concisely.
  • Ability to complete multiple tasks quickly and efficiently.
  • Ability to master new skills, methods and instrumentation quickly.
  • Ability to work independently and as a team player, and to follow supervisory direction.

EDUCATION REQUIREMENTS:

B.S. or M.S. degree in Chemistry or the equivalent knowledge and experience is required.

JOB CONDITIONS:

Work is carried out in a typical chemistry laboratory setting. Work may require frequent sitting, standing, walking and lifting and/or carrying of chemicals or chemical containers. Work may also require sitting and working at a computer or standing at a laboratory bench for long periods of time.

COMPENSATION AND BENEFITS:

Salary dependent on experience/education. Company-paid benefits include: medical, dental, and vision insurance coverage, 401K, sick leave, vacation, and company holidays.

Job Type: Full-time

TO APPLY:

Email your resume and cover letter to chemjob@biotium.com.

Research Associate, Process Development

JOB TITLE: Research Associate, Process Development

LOCATION: Fremont, CA

DATE EFFECTIVE: Immediately

JOB OBJECTIVE:

This role will be responsible for scale-up of protein purification processes in order to generate milligram to gram-scale quantities of recombinant proteins to support life science reagent manufacturing. The successful candidate will be highly proficient in recombinant protein expression and purification from various host cell systems (e.g. E. coli and mammalian cells).

ESSENTIAL DUTIES:

  • Preparation and sterilization of media and culture-ware.
  • Protein expression from shake flask scale to bioreactor systems using mammalian or E. coli cultures.
  • Maintenance of bacterial stocks.
  • Isolate, purify, and analyze expressed proteins.
  • Independently design and perform experiments at the laboratory bench, make detailed and general observations, and analyze data.
  • Write protocols, and SOPs, and perform production and quality control testing of products in compliance with our ISO 9001:2015 quality system.

MANDATORY QUALIFICATIONS:

  • B.S. in Biochemistry, Biology or a related field with +1 years of research experience, or M.S.
  • Experience with E. coli cell culture is required.
  • Capable of setting up assays independently for molecule characterization, interpretation of technical and laboratory data.
  • An independent self-starter who enjoys problem solving and troubleshooting.
  • Ability to organize tasks effectively, maintain accurate records and documentation of results.
  • Excellent time management skills and ability to complete multiple tasks quickly and efficiently in a flexible and fast-paced research environment.
  • Ability to master new skills, methods and instrumentation quickly.
  • Excellent verbal and written communication skills to present scientific results clearly and concisely.

PREFERRED QUALIFICATIONS:

  • Experience with recombinant protein purification using AKTA instruments (or similar) is a plus.
  • Experience with preparative column chromatography (including ion exchange, IMAC, HIC, SEC, etc.).
  • Experience with buffer exchange and filtration (membrane filtration, dialysis, TFF, etc.).
  • Experience with protein analysis.
  • Experience with cloning, vector construction, sequence analysis, plasmid purification, and characterization of cell lines.

JOB CONDITIONS:

Work is carried out in a typical biochemistry/chemistry laboratory setting. Work may require frequent sitting, standing, walking and lifting and/or carrying of chemicals or chemical containers. Work may also require sitting and working at a computer or standing at a laboratory bench for long periods of time.

EDUCATION REQUIREMENTS:

B.S. in Biochemistry, Biology or a related field with +1 years of research experience, or M.S.

COMPENSATION AND BENEFITS:

Salary dependent on experience/education. Company-paid benefits include: medical, dental, and vision insurance coverage, 401K, sick leave, vacation, and company holidays.

TO APPLY:

Email your resume and cover letter to biojob@biotium.com.

Research Associate, Molecular Biology

JOB TITLE: Research Associate, Molecular Biology

LOCATION: Fremont, CA

DATE EFFECTIVE: Immediately

JOB OBJECTIVE:

This role will be responsible for performing production-scale nucleic acid purifications and nucleic acid detection using fluorescence assays and quantitative PCR. The successful candidate will have experience handling DNA and RNA, and be capable of demonstrating careful pipetting technique in sensitive assays. This individual will play an important supporting role in the design, optimization, and assessment of new nucleic acid detection products.

ESSENTIAL DUTIES:

  • Purify high-quality RNA from a variety cell sources.
  • Prepare DNA and RNA solutions, buffers, and other components for molecular biology kits.
  • Perform sensitive nucleic acid detection assays as part of quality control.
  • Perform production and quality control testing of products in compliance with our ISO 90 01:2015 quality system.
  • Assist in the development of new molecular biology assays.
  • Respond quickly to changing priorities and handle multiple projects.
  • Assist in identifying and solving problems in protocol designs.
  • Independently design and perform experiments at the laboratory bench, make detailed and general observations, and analyze data.
  • Clearly and accurately present data in department meetings.
  • Meticulously record data in laboratory notebook and production forms and curate digital files.

MANDATORY QUALIFICATIONS:

  • B.S. in Molecular Biology, Biochemistry or a related field with +1 years of research experience, or M.S.
  • Hands-on experience with nucleic acid characterization techniques (electrophoresis, microplate-based assay, qPCR, RT-PCR).
  • Hands-on experience with nucleic acid purification, and in particular experience with careful handling of RNA.
  • Careful, precise and accurate laboratory techniques, with a focus on accurate pipetting.
  • Capable of setting up bioscience assays independently for molecule characterization.
  • An independent self-starter who enjoys problem solving and diagnostic troubleshooting.
  • Excellent time management skills and ability to complete multiple tasks quickly and efficiently.
  • Ability to master new skills, methods and instrumentation quickly.
  • Ability to work independently and as a team player, and to follow supervisory direction.
  • Excellent verbal and written communication skills to present scientific results clearly and concisely.

PREFERRED QUALIFICATIONS:

  • Experience with RNA purification and handling.
  • Experience with fluorescence-based nucleic acid quantitation assays.
  • Experience with fluorescence-based qPCR or RT-PCR assays.
  • Experience with cell culture (mammalian, bacterial, other).
  • Industrial experience in biotechnology or product development.

JOB CONDITIONS:  Work is carried out in a typical biochemistry/chemistry laboratory setting. Work may require frequent sitting, standing, walking and lifting and/or carrying of chemicals or chemical containers. Work may also require sitting and working at a computer or standing at a laboratory bench for long periods of time.

EDUCATION REQUIREMENTS:  B.S. in Molecular Biology, Biochemistry or a related field with +1 years of research experience, or M.S.

COMPENSATION AND BENEFITS:  Salary dependent on experience/education. Company-paid benefits include: medical, dental, and vision insurance coverage, 401K, sick leave, vacation, and company holidays.

TO APPLY:

Email your resume and cover letter to biojob@biotium.com.