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Innovative Chemistry. Clearer Biology.

Biotium is a leading life science reagent manufacturer and supplier devoted to providing high-quality and innovative fluorescent tools that fuel scientific discovery. Our collaborative team of experienced chemists and biologists, who are at the forefront of fluorescent dye design, apply chemistry-based principles toward producing solutions for unmet challenges in life science and medical research. Since its founding in 2001, Biotium has developed over 30 patented technologies including GelRed® dyes, CF® dyes, NucView® Caspase-3 Substrates, EvaGreen® dyes, and TrueBlack® Background Reducers. Many of these technologies have been licensed out to leading life science technology companies worldwide.

See our current job openings below for opportunities to join our team.

Staff Scientist (Chemistry)

JOB TITLE: Staff Scientist (Chemistry)

LOCATION: Fremont, California

JOB FUNCTIONS:

This Staff Scientist (Chemistry) position focuses on the production of fluorescent reagents and improvement of manufacturing processes. This position will also involve developing novel fluorescent reagents for various detection platforms such as flow cytometry, microscopy, and live cell imaging systems.

JOB OBJECTIVE:

Under direct supervision from the VP of Research and Development, the Staff Scientist will perform R&D and production projects utilizing/modifying existing protocols. The Staff Scientist will also design and execute new protocols for custom orders and new production items. The Staff Scientist will be expected to use his/her extensive knowledge of chemistry to successfully complete complex multi-step reactions.

ESSENTIAL DUTIES:

  • Under general guidelines, independently plan, organize, and perform the synthesis of new and existing products to meet product specifications. Plans production schedule for on-time delivery of products.
  • Write, review and revise, as necessary, manufacturing and QC protocols for clarity, process improvement and/or material changes as prescribed by procedures and policies.
  • Independently adapt or modify methods to achieve technical objectives.
  • Address and report problems in daily production and propose effective countermeasures.
  • Proactively identify areas for improvement and drive efficiency results.
  • Use highly specialized equipment and instrumentation in daily functions.
  • Critically analyze data and interpret experimental results.
  • Write protocols and lab notebooks documenting processes and improvements consistent with ISO 9001 standards.
  • Work as an active team member assisting the implementation of new processes within the production group.
  • Maintain a high level of professional expertise through familiarity with current scientific literature with respect to compounds, reactions, and processes.
  • Maintain a safe and clean work environment.

MANDATORY QUALIFICATIONS:

  • Demonstrated competence in reaction design, process improvement, and product purification.
  • Depth of synthetic experience from milligram to kilogram scale
  • Excellent time management skills and ability to work independently
  • Proven ability to lead and provide work direction.
  • Careful, precise and accurate laboratory techniques.
  • Proficiency in the analysis and interpretation of technical and laboratory data.
  • Ability to effectively organize tasks, data and documentation.
  • Skilled in problem solving and diagnostic troubleshooting.
  • Proficiency in the maintenance of accurate records involving production,analysis,and the documentation of results.
  • Verbal and written communication skills, and ability to express scientific results clearly and concisely.
  • Ability to complete multiple tasks quickly and efficiently.
  • Ability to master new skills, methods, and instrumentation quickly.
  • Ability to work independently and as a team player, and to follow supervisory direction.

JOB CONDITIONS:

Work is carried out in a typical chemistry laboratory setting. Work may require frequent sitting, standing, walking, lifting, and/or carrying of chemicals or chemical containers. Work may also require sitting and working at a computer or standing at a laboratory bench for long periods of time.

EDUCATION REQUIREMENTS:

Ph.D degree in Chemistry, or other related discipline, or the equivalent knowledge and experience is required.

COMPENSATION AND BENEFITS:

Salary depending on experience/education. Standard company-paid benefits (health insurance, 401k matching, sick, vacation and holiday)

TO APPLY:
Email your resume and cover letter to chemjob@biotium.com.

Chemistry Technician I (Chemistry)

JOB TITLE: Chemistry Technician I

LOCATION: Fremont, California

JOB OBJECTIVE:

Under the direct supervision from senior chemist, perform chemical purifications using chromatography including preparative HPLC or gravity chromatography; carry out chemical synthesis using standard protocols; carry out chemical analyses using modern instruments including analytical HPLC, LC-MS, TLC, UV/Vis and fluorescence spectrophotometry.

ESSENTIAL DUTIES:

  • Perform purifications of chemical compounds by preparative HPLC or gravity chromatography.
  • Perform production of chemical compounds by following ISO protocols
  • Perform analytical HPLC on compounds.
  • Must possess sufficient chemistry knowledge and HPLC experiences to develop HPLC conditions for both analytical and preparative purposes using chemical structure information provided.
  • Perform LC-MS on chemical compounds and interpret the results.
  • Perform UV/Vis and/or fluorescence spectrophotometry on dyes.
  • Responsible for the maintenance and minor repair of the above instruments.
  • Write protocols for laboratory procedures and accurately and clearly document results and observations in lab notebooks.
  • Work as an active team member assisting the implementation of new processes within the chemistry group and the company.
  • Maintain high level of professional expertise through familiarity with current scientific literature with respect to compounds, reactions, and processes.
  • Maintain a safe and clean work environment.

 MANDATORY QUALIFICATIONS:

  • Demonstrated competence in analytical and preparative HPLC.
  • Excellent time management skills and ability to work independently required.
  • Careful, precise and accurate laboratory techniques.
  • Proficiency in the analysis and interpretation of technical and laboratory data.
  • Ability to effectively organize tasks, data and documentation.
  • Skilled in problem solving and diagnostic troubleshooting.
  • Proficiency in the maintenance of accurate records involving production and analysis and the documentation of results.
  • Verbal and written communication skills and ability to express scientific results clearly and concisely.
  • Ability to complete multiple tasks quickly and efficiently.
  • Ability to master new skills, methods and instrumentation quickly.
  • Ability to work independently and as a team player, and to follow supervisory direction.

EDUCATION REQUIREMENTS:

B.S. or M.S. degree in Chemistry or the equivalent knowledge and experience is required.

JOB CONDITIONS:

Work is carried out in a typical chemistry laboratory setting. Work may require frequent sitting, standing, walking and lifting and/or carrying of chemicals or chemical containers. Work may also require sitting and working at a computer or standing at a laboratory bench for long periods of time.

COMPENSATION AND BENEFITS:

Salary dependent on experience/education. Company-paid benefits include: medical, dental, and vision insurance coverage, 401K, sick leave, vacation, and company holidays.

Job Type: Full-time

TO APPLY:
Email your resume and cover letter to chemjob@biotium.com.

Bioconjugation Scientist (Bioconjugation)

JOB TITLE: Bioconjugation Scientist (Bioconjugation)

LOCATION: Fremont, CA

JOB OBJECTIVE:

Synthesis, purification and characterization of antibody/biomolecule conjugates with fluorescent dyes, fluorescent proteins, fluorescent tandem dyes, enzyme reporters and polymeric scaffold. Research and development leading to commercialize bioconjugation products. The successful candidate will possess a strong background in chemistry and bioconjugation chemistry and have experience performing bioconjugation reactions, protein purification and requisite analytical techniques.

ESSENTIAL DUTIES:

  • Synthesize bioconjugates using established chemistries.
  • Contribute to the development of new bioconjugation methodologies.
  • Evaluate new bioconjugation methods from the literatures.
  • Purify bioconjugates by size exclusion chromatography, ion-exchange chromatography, affinity chromatography and hydrophobic interaction chromatography.
  • Optimize protein and antibody conjugation and purification methods.
  • Develop and implement assays for quality control.
  • Create SOPs and transfer to manufacturing.
  • Provide technical support and troubleshooting to manufacturing.
  • Working knowledge of AKTA platform or equivalents.
  • Characterize bioconjugates using multiple techniques such as UV/Vis, fluorescence, HPLC, MS and particle analyzer.
  • Mentor research associates in experimental design, data interpretation, laboratory and instrument techniques and best practices.
  • Operates lab instruments according to established procedures and prepares reagents as needed.
  • Critically analyzes, summarizes, and reports data generated from experiments, draws conclusions from experimental results and recommends and executes required follow-up actions with consideration of prior experimental findings (self and others) with minimal supervision.
  • Presents data at team meetings or to small focus groups that may include representatives from other departments and/or outside parties and participates in brainstorming and troubleshooting sessions within or between teams, offering and implementing solutions to problems.
  • Performs and is involved in the planning and documentation of verification activities to ensure that newly developed products meet the pre-determined product specifications,
  • May facilitate the transfer research products to Manufacturing/Operations and is involved in completion and release of enabling documentation for newly developed products by ensuring all relevant technical information is incorporated into the appropriate documents.
  • Maintains familiarity with current technology related information and/or literature and conducts project related information searches and may be involved in extensive literature searches.
  • Trains others in laboratory procedures and processes, and in the design, execution, and analysis of experiments. Provides feedback to supervisor on training progress.
  • Performs other duties and assumes additional departmental responsibilities as required. Performs other assignments and tasks as directed.
  • Demonstrates excellent written and verbal communication skills within and between departments. Maintains appropriate laboratory records, notebooks, and other formal company documentation, as required.
  • Works under minimal supervision, receiving no instructions on routine work, general instructions on new assignments, and detailed instructions or training on new applications or responsibilities
  • Works on complex problems where analysis of situations or data requires an in-depth evaluation of various factors, and exercises judgment within broadly defined practices and policies to determine appropriate conclusion and follow up action.

MANDATORY QUALIFICATIONS:

PhD degree in Chemistry or Biological Science with 3 year experience in bioconjugation or MS/B Sc degree in Chemistry or Biological Science with 7 year experience in bioconjugation.

PREFERRED QUALIFICATIONS:

  • Solid knowledge in chemistry, biochemistry and fluorescent dye chemistry
  • Strong analytical methods such as chromatography, spectrophotometry, gel electrophoresis and particle analyzer.
  • An independent self-starter who enjoys problem solving and diagnostic troubleshooting.
  • Excellent time management skills and ability to complete multiple tasks quickly and efficiently in a flexible and fast-paced research environment.
  • Careful, precise and accurate laboratory techniques.
  • Ability to effectively organize tasks, maintain accurate records and documentation of results.
  • Ability to master new skills, methods and instrumentation quickly.
  • Ability to work independently and as a team player, and to follow supervisory direction.
  • Excellent verbal and writing skills for internal and customer-facing communication.

JOB CONDITIONS: 

Work is carried out in a typical biology laboratory setting. Work may require frequent sitting, standing, walking and lifting and/or carrying of chemicals or chemical containers. Work may also require sitting and working at a computer or standing at a laboratory bench for long periods of time.

COMPENSATION AND BENEFITS: 

Salary dependent on experience/education. Company-paid benefits include: medical, dental, and vision insurance coverage, 401K, sick leave, vacation, and company holidays.

TO APPLY:

Email your resume and cover letter to chemjob@biotium.com.

Research Associate I, Protein Science (Bioscience)

DESCRIPTIVE SUMMARY
This role will be responsible for scale-up of protein purification processes to generate milligram to gram-scale quantities of recombinant proteins to support life science reagent manufacturing. The successful candidate will be highly proficient in recombinant protein expression and purification from various host cell systems (e.g. E. coli and mammalian cells).

Key Performance Indicators

  • Generates reproducible experimental testing data in support of new product development, customer troubleshooting, and product improvement.
  • Performs production and quality control testing of products in compliance with Biotium’s ISO 9001:2015 quality system.
  • Follows established protocols with minimal direct supervision.
  • Makes detailed and general experimental observations, analyzes data, and presents data regularly in department meetings.
  • Consistently and accurately records and curates R&D and production data.

Core Functions

  • Preparation and sterilization of media and culture-ware.
  • Protein expression from shake flask scale to bioreactor systems using mammalian or E. coli cultures.
  • Maintenance of bacterial stocks.
  • Isolate, purify, and analyze expressed proteins.
  • Independently design and perform experiments at the laboratory bench, make detailed and general observations, and analyze data.
  • Write protocols, and SOPs, and perform production and quality control testing of products in compliance with our ISO 9001:2015 quality system.

WINNING BEHAVIORS, COMPETENCIES, AND SKILLS
This person should have an outgoing personality and positive demeanor with a track record of working well with others in a team environment. They should be highly motivated and have a strong desire to learn new skills, techniques, and instrumentation. They should have excellent verbal and written communication skills to present scientific results clearly and concisely. They will need to follow procedures and demonstrate good documentation and record keeping.

Personality and communication (soft skills):

  • Fluent in English, with excellent verbal and written communication skills.
  • Detail-oriented, team player, self-motivated, fast-learner, multi-tasking and prioritizing, fast-paced, efficient in time-management.
  • Able to work independently and as a team player.
  • Able to follow supervisory direction.
  • An independent self-starter who enjoys problem solving and diagnostic troubleshooting.

Hard skills:
Prior protein purification experience is not required, training will be provided. However, prior experience with any of the following techniques is a plus:

  • Experience with E. coli cell culture.
  • Experience with recombinant protein purification using AKTA instruments (or similar).
  • Experience with preparative column chromatography (including IEX, IMAC, HIC, SEC, etc.).
  • Experience with buffer exchange and filtration (membrane filtration, dialysis, TFF, etc.).
  • Experience with protein analysis.
  • Experience with cloning, vector construction, sequence analysis, plasmid purification, and characterization of cell lines.

EXPERIENCE
Education: B.S. in Biochemistry, Biology, or a related field with +1 years of research experience, or M.S.
Work Experience: Hands-on laboratory experience in academic or industrial setting.

Industry Knowledge:

  • Ability to organize tasks effectively, maintain accurate records and documentation of results.
  • Ability to think and work effectively under pressure and accurately prioritize and complete tasks within established timeframes.
  • Ability to master new skills, methods, and instrumentation quickly.
  • Ability to assume responsibility and exercise good judgement when making decisions within the scope of the position.
  • Ability to maintain confidentiality.
  • Ability to comply with all Biotium policies and procedures.
  • Ability to perform the job safely with respect to others, property, and individual safety.
  • Excellent verbal and written communication skills to present scientific results clearly and concisely.

COMPENSATION AND BENEFITS
Salary dependent on experience/education. Company-paid benefits include: medical, dental, and vision insurance coverage, 401K, sick leave, vacation, and company holidays.

TO APPLY:
Email your resume and cover letter to biocareer@biotium.com.

Research Technician (Process Development)

JOB TITLE: Research Technician (Process Development)

LOCATION: Fremont, CA

JOB OBJECTIVE:

This role will be responsible for scale-up of protein purification processes to generate milligram to gram-scale quantities of recombinant proteins, specifically Taq Polymerase, to support life science reagent manufacturing.

ESSENTIAL DUTIES:

  • Preparation and sterilization of media and culture-ware.
  • Protein expression from shake flask scale to bioreactor systems using E. coli cultures.
  • Maintenance of bacterial stocks.
  • Isolate, purify, and analyze expressed proteins.
  • Perform production and quality control testing of products in compliance with our ISO 9001:2015 quality system.

MANDATORY QUALIFICATIONS:

  • B.S. in Biochemistry, Biology or a related field.
  • Ability to organize tasks effectively, maintain accurate records and documentation of results.
  • Excellent time management skills and ability to complete multiple tasks quickly and efficiently in a flexible and fast-paced research environment.
  • Ability to master new skills, methods and instrumentation quickly.
  • Excellent verbal and written communication skills to present scientific results clearly and concisely.

PREFERRED QUALIFICATIONS:

Prior protein purification experience is not required, training will be provided. However, prior experience with any of the following techniques is a plus:

  • E. coli cell culture.
  • Protein purification using AKTA instruments (or similar).
  • Column chromatography (including ion exchange, IMAC, HIC, SEC, etc.).
  • Buffer exchange and filtration (membrane filtration, dialysis, TFF, etc.).
  • SDS-PAGE or other protein analysis methods.

JOB CONDITIONS:

Work is carried out in a typical biochemistry/chemistry laboratory setting. Work may require frequent sitting, standing, walking, and lifting and/or carrying of chemicals or chemical containers. Work may also require sitting and working at a computer or standing at a laboratory bench for long periods of time.

EDUCATION REQUIREMENTS:

B.S. in Biochemistry, Biology or a related field.

COMPENSATION AND BENEFITS:

$50,000 to $70,000 per year dependent on experience/education. Company-paid benefits include: medical, dental, and vision insurance coverage, 401K, sick leave, vacation, and company holidays.

TO APPLY:
Email your resume and cover letter to biocareer@biotium.com.

Support Scientist/Technical Writer (REMOTE)

JOB TITLE: Support Scientist/Technical Writer (REMOTE)

DESCRIPTIVE SUMMARY

As part of the technical support team, you will provide product recommendations, technical advice, and troubleshooting for customers and distributors. As a technical writer you will work with our scientists and marketing team members to create and update official product documents as well as creative marketing materials. This includes but is not limited to product information sheets, safety data sheets, flyers, and brochures. This position will be entirely remote within the United States.

KEY PERFORMANCE INDICATORS

  • Ability to establish rapport and develop strong professional partnerships with major distribution channels/customers.
  • Ability to diagnose and resolve technical issues from scientific data and communicate effectively through phone or email to our customers/distribution partners in the life sciences industry.
  • Ability to create well written technical articles that provide interest and value to potential customers in the life sciences.
  • Ability to work independently and complete technical writing assignments in a timely manner.

CORE FUNCTIONS

  • With guidance from our scientific team, provide product technical support and product recommendations to customers and distributors by phone and email.
  • Help investigate potentially non-conforming products based on customer feedback.
  • Create and revise customer-facing documents including product information sheets and safety data sheets.
  • Create and edit website content including blogs, highlighted citations, app notes, and reference lists.
  • Communicate with research, marketing, and customer service teams to provide insight on customer needs and potential room for improvement.

WINNING BEHAVIORS, COMPETENCIES, AND SKILLS

  • The successful candidate will have exceptional teamwork, communication, organizational, and time management skills.
  • Effective communication (presentations, correspondence, and 1-on-1) and interpersonal skills with the ability to interact effectively and professionally at all levels of the organization.
  • Ability to meet deadlines and juggle multiple priorities in a fast-paced, team-oriented environment.
  • Outgoing, upbeat and confident personality.
  • Proficient PC skills (Word, Excel, Outlook, PowerPoint, CRM software, internet).

EXPERIENCE

Education:

  • Bachelor’s degree in biological/life sciences.
  • Master’s degree or PhD in the biological/life sciences preferred.

Work Experience:

  • Experience in Cell Biology, Molecular Biology, or related life science field.

Industry Knowledge:

  • Experience with fluorescence-based technologies a plus.
  • Knowledge of life science research markets with knowledge of competitors.

COMPENSATION AND BENEFITS

Commensurate with experience/education.  Biotium Inc. offers a competitive and comprehensive employee benefits package, including company paid medical, dental, vision and life insurance, holiday, sick and vacation and 401K matching.

TO APPLY:
Email your resume and cover letter to biocareer@biotium.com.

Quality Assurance Specialist

JOB TITLE: Quality Assurance Specialist

JOB OBJECTIVE

This position has a role in enhancing our quality management system by defining, maintaining, and improving site level company policies, procedures, Quality Management System relative to all applicable regulations and standards. The QA Specialist will evaluate existing processes to identify potential gaps and best practices and work with subject matter experts across the company to implement effective & efficient quality system processes.

ESSENTIAL DUTIES

Primary Duties

  • Carefully maintain compliance and nonconformance processing through records and tracking systems, including root cause and corrective actions
  • Verify quality assurance activities with internal reporting and audits
  • Identify training needs and take action to ensure company-wide compliance
  • Analyze and investigate product complaints or reported quality issues to ensure closure in accordance with company guidelines and external regulatory requirements
  • Provide training and support to quality assurance team on systems, policies, procedures, and core processes
  • Ensure that equipment is monitored, maintained, and within calibration and that new equipment is processed according to ISO9001 standards
  • Work closely with production and customer service operations management to conduct quality investigations including root cause identification, CAPA, effectiveness check and timely completion of documentation
  • Communicate effectively with all levels of personnel in manufacturing and support departments
  • Effectively coordinate internal teams for quality requirements
  • Other activities as assigned by QA Management

Secondary Duties

  • Assist with routine ISO internal audits
  • Make recommendations for the improvement of any procedures or processes that will result in better efficiency, cost reduction, employee safety and/or improved product quality

MANDATORY QUALIFICATIONS

  • Minimum of 2 years’ experience in an ISO manufacturing environment with a minimum of 3 years in the biotechnology industry
  • Working knowledge of international standards and regulatory requirements including but not limited to ISO 9001 and 21 CFR Part 820
  • Effective problem solving skills to successfully deal with problems varying in complexity
  • Ability to write technical reports, manufacturing procedures, and training material
  • Ability to define problems, collect data, establish facts, and draw valid conclusions
  • Able to work in cross functional team environments
  • Able to manage multiple projects or assignments with minimal supervision
  • Candidate must be a strong team player, self-motivated and willing to learn new techniques and concepts in a fast-paced highly interdisciplinary environment
  • Strong organizational skills and attention to detail
  • Excellent verbal and written communication skills

PREFERRED QUALIFICATIONS

  • Previous experience with ERP system
  • Previous experience with deviations, CAPAs, and Root Cause

JOB CONDITIONS

Office and manufacturing/laboratory environment

EDUCATION REQUIREMENTS

B.S. or M.S. in science, engineering, or closely related discipline.

COMPENSATION AND BENEFITS

Salary depends on experience/education. Standard company-paid benefits (health insurance, 401k matching, sick, vacation and holiday).

TO APPLY:
Email your resume and cover letter to adminjob@biotium.com.

Intern, Protein Science (Bioscience)

DESCRIPTIVE SUMMARY
Under the direct supervision of a Biotium Scientist, perform experiments to aid in process development of protein production. Essential duties will include but are not limited to:

  • Preparation and sterilization of media and culture-ware
  • Preparation of stock solutions
  • Protein expression using E. coli cultures
  • Analysis of purified proteins

KEY PERFORMANCE INDICATORS

  • Completion of experiments following detailed instructions
  • Meticulous documentation of procedures and results

CORE FUNCTIONS

  • Carry out R&D tests under supervision of a scientist
  • Make detailed observations and document results in laboratory notebook
  • Compile and annotate data, present results at weekly R&D meetings

Work is carried out in a typical biochemistry/chemistry laboratory setting. Work may require frequent sitting, standing, walking, and lifting and/or carrying of chemicals, chemical containers, or equipment. Work may also require sitting and working at a computer or standing at a laboratory bench for long periods of time.

WINNING BEHAVIORS, COMPETENCIES, AND SKILLS
This person should have an outgoing personality and positive demeanor with a track record of working well with others in a team environment. They will need to follow procedures and demonstrate good documentation and record keeping.

  • Fluent in English, with excellent verbal and written communication skills
  • Detail-oriented, fast-learner, team player
  • Efficient in time-management
  • Able to follow supervisory direction
  • Proficient PC skills (Word, Excel)

EXPERIENCE
Education: The position is open to students who have completed courses in biology, molecular biology, microbiology, or biochemistry. No laboratory experience is required. This internship provides an opportunity to get hands-on training in widely used biology techniques and learn practical applications of fluorescence technologies from experienced scientists in a friendly, small company environment.

COMPENSATION AND BENEFITS
$24 per hour (Monday through Friday, 8-hour workday). Due to its temporary nature, this internship position is not eligible for Biotium paid standard benefits.

TO APPLY:
Email your resume, cover letter, and transcript to biocareer@biotium.com.