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Can synthetic glycosaminoglycans prevent sinusitis?

Glycosaminoglycans (GAGs) are unbranched polysaccharides present in extracellular matrix and mucosal surfaces. Various GAGs have been shown to have anti-inflammatory properties. In a recent publication, Pulsipher and colleagues tested whether the synthetic GAG GM-0111 could protect nasal sinuses from inflammation. Fluorescence imaging of GM-0111 labeled with CF™647 hydrazide was used to confirm that GM-0111 effectively coated and penetrated sinus mucosa for at least 24 hours after intranasal administration in mice. Furthermore, topically applied GM-0111 prevented sinus tissue inflammation and cell death in a mouse model of rhinosinusitis, suggesting therapeutic potential for exogenous GAGs for treating inflammation of the upper airways.

To read the original article, click here.

Pulsipher A, Qin X, Thomas AJ, Prestwich GD, Oottamasathien S, Alt JA. Prevention of sinonasal inflammation by a synthetic glycosaminoglycan. Int Forum Allergy Rhinol. 2016. DOI: 10.1002/alr.21865.


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