Glycosaminoglycans (GAGs) are unbranched polysaccharides present in extracellular matrix and mucosal surfaces. Various GAGs have been shown to have anti-inflammatory properties. In a recent publication, Pulsipher and colleagues tested whether the synthetic GAG GM-0111 could protect nasal sinuses from inflammation. Fluorescence imaging of GM-0111 labeled with CF™647 hydrazide was used to confirm that GM-0111 effectively coated and penetrated sinus mucosa for at least 24 hours after intranasal administration in mice. Furthermore, topically applied GM-0111 prevented sinus tissue inflammation and cell death in a mouse model of rhinosinusitis, suggesting therapeutic potential for exogenous GAGs for treating inflammation of the upper airways.
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Pulsipher A, Qin X, Thomas AJ, Prestwich GD, Oottamasathien S, Alt JA. Prevention of sinonasal inflammation by a synthetic glycosaminoglycan. Int Forum Allergy Rhinol. 2016. DOI: 10.1002/alr.21865.
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