Far-red fluorescent probe with high affinity for Aβ plaques/aggregates, that can be used for fluorescent staining of brain sections and in vivo detection of Aβ1-42 aggregates in small animals.
DCDAPH (1,1-dicyano-6-(4-N,N-dimethylaminophenyl)-1,3,5-hexatriene) can be used for fluorescent staining of brain sections, as well as in vivo detection of Aβ1-42 aggregates by small animal near-IR imaging1.
- Far-red fluorescent probe with high affinity for Aβ plaques/aggregates
- Affinity for Aβ1-42 aggregates: Ki= 37 nM, Kd=27 nM
- Dark purple solid
- λEx/λEm = 597/665 nm (PBS)
- Store at -20°C and protect from light, especially in solution
- MW: 249.31
1. J. Am. Chem. Soc. dx.doi.org/10.1021/ja4052922
You may also like…
PathoGreen™ Histofluorescent Stain, 1000X in water
PathoGreen™ Histofluorescent Stain is an anionic green fluorescent dye functionally similar to Fluoro-Jade dyes. These dyes stain degenerating neurons and their processes after exposure to a variety of neurotoxic insults in brain sections and cultured neurons.
Congo Red “High Purity Grade”
Congo Red has been used in microscopy for staining elastic fibers and bacteria. Amyloid protein, an abnormal protein aggregate associated with various pathologies, is commonly detected in tissue with Congo Red.
Thioflavin T, High Purity Grade
A cell-permeable dye that exhibits enhanced fluorescence upon binding to amyloid fibrils, and has been used in histology and for protein characterization.
Nerve Terminal Staining Kits
Nerve Terminal Staining Kits contain Biotium's nerve terminal dyes and accessories for washing away or quenching extracellular dye fluorescence.
α-Bungarotoxin, CF® Dye and Other Conjugates
Conjugates of α-Bungarotoxin labeled with a selection of our CF® Dyes and other labels. Labeled α-bungarotoxin conjugates can be used for staining nicotinic acetylcholine receptors at neuromuscular junctions in tissue sections.
RedDot™2 Far-Red Nuclear Stain, 200X in DMSO
A far-red cell membrane-impermeant nuclear dye with greater nuclear specificity than Draq7™. Ideal for fixed cell nuclear counterstaining with minimal cytoplasmic RNA staining.