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DCDAPH

DCDAPH (1,1-dicyano-6-(4-N,N-dimethylaminophenyl)-1,3,5-hexatriene) is a far-red fluorescent probe that has high affinity to Aβ plaques. It has been used for fluorescent staining of brain sections and in vivo small animal near-IR imaging.

Product Attributes

Apoptosis/viability marker

Amyloid stain

Colors

Far-red, Near-infrared

Excitation/Emission

597/665 nm

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5 mg
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Product Description

DCDAPH (1,1-dicyano-6-(4-N,N-dimethylaminophenyl)-1,3,5-hexatriene) is a far-red fluorescent probe that has proved to have affinity to Aβ plaques. It has been used for fluorescent staining of brain sections, as well as in vivo detection of Aβ1-42 aggregates by small animal near-IR imaging1.  DCDAPH has high affinity (Ki= 37 nM, Kd=27 nM) to Aβ1-42 aggregates.

  • Dark purple solid
  • λExEm = 597/665 nm (PBS)
  • Store at -20°C and protect from light, especially in solution
  • C16H15N3
  • MW: 249.31

References

1. J. Am. Chem. Soc. dx.doi.org/10.1021/ja4052922

 

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