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PathoGreen™ Histofluorescent Stain, 1000X in water

PathoGreen™ Histofluorescent Stain is an anionic green fluorescent dye functionally similar to Fluoro-Jade dyes. These dyes stain degenerating neurons and their processes after exposure to a variety of neurotoxic insults in brain sections and cultured neurons.

Product Attributes

Apoptosis/viability marker

Dead cell stain

For live or fixed cells

For fixed cells/tissue sections

Detection method/readout

Fluorescence microscopy

Assay type/options

Endpoint assay

Colors

Green

Excitation/Emission

497/520 nm

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Note: Due to operating restrictions related to our COVID-19 response, primary antibody conjugates of R-PE, APC, PerCP, HRP, or AP are temporarily unavailable. All other antibody options are still available. We apologize for the inconvenience. Please see our easy-to-use Mix-n-Stain™ Antibody Labeling Kits for labeling antibodies with R-PE, APC, tandem dyes, and enzymes.
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Product Description

PathoGreen™ Histofluorescent Stain is an anionic green fluorescent dye (Ex/Em 497/520 nm) functionally similar to Fluoro-Jade® dyes. These dyes stain degenerating neurons and their processes after exposure to a variety of neurotoxic insults in brain sections and cultured neurons. The mechanism of neuronal staining by anionic fluorescent dyes has not been determined. It has been proposed that the negatively charged dyes bind to positively charged polyamines or other molecules specifically generated in dying neurons.

Fluoro-Jade is a registered trademark of Histo-Chem, Inc.

References

Shimada, R. et al. (2014). Neurological Research 36(4), 239-246. doi:10.1179/1743132813Y.0000000289

 

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