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DNAstorm™ Kit for Isolation of DNA from FFPE Tissue Samples

Superior DNA extraction from FFPE samples, due to the enhanced removal of formaldehyde-induced damage, providing DNA with higher yield and quality and greater amplifiability.

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Note: Due to operating restrictions related to our COVID-19 response, primary antibody conjugates of R-PE, APC, PerCP, HRP, or AP are temporarily unavailable. All other antibody options are still available. We apologize for the inconvenience. Please see our easy-to-use Mix-n-Stain™ Antibody Labeling Kits for labeling antibodies with R-PE, APC, tandem dyes, and enzymes.
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Product Description

Formalin-fixed tissue samples are a challenge for DNA extraction, often resulting in low yields and poor performance in subsequent steps. Most existing methods rely on heat to remove crosslinks and adducts, which is only partially effective and leads to additional fragmentation of labile nucleic acids. Powered by proprietary CAT5™ technology, the DNAstorm™ extraction kit enhances the removal of formaldehyde-induced damage and provides DNA with higher yield and quality and greater amplifiability. The DNAstorm™ kit is the best solution for next-generation sequencing and other advanced applications.

  • Purify higher quality DNA with less fragmentation
  • Extract higher yields of amplifiable DNA than heat-based methods
  • CAT5™ technology for enzymatic reversal of formaldehyde crosslinking
  • Gentle treatment of samples with no high temperature or harsh solvents
  • Better results in downstream analysis like PCR, microarray, or next-generation sequencing
  • Simple workflow

The DNAstorm™ extraction kit greatly accelerates the removal of formaldehyde damage and allows recovery of higher quality nucleic acids. This results in higher yields, more intact RNA or DNA, and better results in downstream analysis like PCR, microarray, or next-generation sequencing (NGS). We also offer the RNAstorm™ kit for extraction of high-quality RNA from FFPE tissue samples. The RNAstorm™ and DNAstorm™ kits can be combined to obtain both pure DNA and RNA from the same tissue section. See our App Note – Dual DNA and RNA Extraction From a Single FFPE Sample.

DNA from four different FFPE tumor samples (colorectal, lung, bladder, and esophagus) was extracted using the DNAstorm™ FFPE kit along with a popular competitor’s kit. Equal amounts (500 ng) of DNA were loaded and run on a pulsed field gel. Significant improvements in average DNA size are seen using the DNAstorm™ kit. “Kit R” represents a competitive commercial DNA FFPE extraction kit.

References

  1. Am J Surg Pathol, 43, 1720 DOI: 10.1097/PAS.0000000000001338
 

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