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Lewis-Y Monoclonal Mouse Antibody (A70-C/C8)

This antibody recognizes a carbohydrate epitope common to the tumor-associated Lewis Y and Lewis b antigens.

Product Attributes

Antibody number

1411

Reactivity (target)

Lewis-Y

Antibody type

Primary

Host species

Mouse

Clonality

Monoclonal

Clone

A70-C/C8

Isotype

IgM

Molecular weight

Multiple

Synonyms

Lewis Y antigen

Human gene symbol

Not Applicable

Entrez gene ID

Not Applicable

SwissProt

Not Applicable

Unigene

Not Applicable

Immunogen

Live Ls174T cells (human colon carcinoma cell line)

Cellular localization

Cytoplasmic, Membrane/cell surface, Secreted (extracellular)

Species reactivity

Human

Applications

Immunofluorescence, Immunohistology (formalin), Flow cytometry

Application notes

Immunohistology (formalin) 0.5-1 ug/mL, Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min, Immunofluorescence 0.5-1 ug/mL, Flow Cytometry 0.5-1 ug/million cells/0.1 mL, Optimal dilution for a specific application should be determined by user

Positive control

Lung, Colon, Bladder or Hepatocellular Carcinoma

Shipping condition

Room temperature

Storage Conditions

Store at 2 to 8 °C, Note: store BSA-free antibodies at -10 to -35 °C

Shelf life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Regulatory status

For research use only (RUO)

Research areas

Cancer

Tumor expression

Bladder cancer, Colorectal cancer, Renal cancer

Conjugation
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Product Description

This antibody recognizes a carbohydrate epitope common to the tumor-associated Lewis Y and Lewis b antigens (Fucalpha1-2Galbeta1-4/3[Fucalpha1-3/4]GlcNAcbeta). Its specificity was established without doubt with a panel of 86 synthetic mono- and oligosaccharidic structures. Lewis Y is expressed in large bowel tumors and colorectal carcinomas. It may be useful in the classification of human renal and bladder tumors. The Lewis Y antigen has been evaluated as a clinical marker for the diagnosis and prognosis of cholangiocarcinoma, hepatocellular carcinoma and breast cancer.

This antibody is available purified with BSA/azide at 200 ug/mL, or BSA/azide-free at 1 mg/mL.

 

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