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Lewis-Y Monoclonal Mouse Antibody (A70-C/C8)

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Product Attributes

Antibody number

#1411

Antibody reactivity (target)

Lewis-Y

Antibody type

Primary

Host species

Mouse

Clonality

Monoclonal

Clone

A70-C/C8

Isotype

IgM

Molecular weight

Multiple

Synonyms

Lewis Y antigen

Human gene symbol

Not Applicable

Entrez gene ID

Not Applicable

SwissProt

Not Applicable

Unigene

Not Applicable

Immunogen

Live Ls174T cells (human colon carcinoma cell line)

Antibody target cellular localization

Cytoplasmic, Plasma membrane, Secreted (extracellular)

Species reactivity

Human

Antibody application notes

For coating for ELISA, order Ab without BSA, Optimal dilution and staining procedure for a specific application should be determined by user, Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry

Positive control

Lung, Colon, Bladder or Hepatocellular Carcinoma

Shipping condition

Room temperature

Storage Conditions

Store at 2 to 8 °C, Note: store BSA-free antibodies at -10 to -35 °C

Shelf life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Regulatory status

For research use only (RUO)

Antibody/conjugate formulation

Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA, Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide

Antibody research areas

Cancer

Tumor expression

Bladder cancer, Colorectal cancer, Renal cancer

Conjugation
Don’t see what you’re looking for? Contact us for more conjugation options.
Note: Please be advised that primary antibodies with catalog numbers that begin with “BN” will only be offered conjugated to CF®405S, CF®488A, CF®568, CF®594, CF®640R, CF®647, and biotin as of 5/27/2022. However, previously available primary antibody conjugates that are in stock will remain available until inventory is exhausted. Please view the list of available conjugates on the product page. We also recommend our easy-to-use Mix-n-StainTM Antibody Labeling Kits for labeling antibodies with all CF® Dyes. We apologize for the inconvenience.
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Product Description

This antibody recognizes a carbohydrate epitope common to the tumor-associated Lewis Y and Lewis b antigens (Fucalpha1-2Galbeta1-4/3[Fucalpha1-3/4]GlcNAcbeta). Its specificity was established without doubt with a panel of 86 synthetic mono- and oligosaccharidic structures. Lewis Y is expressed in large bowel tumors and colorectal carcinomas. It may be useful in the classification of human renal and bladder tumors. The Lewis Y antigen has been evaluated as a clinical marker for the diagnosis and prognosis of cholangiocarcinoma, hepatocellular carcinoma and breast cancer.

This antibody is available purified with BSA/azide at 200 ug/mL, or BSA/azide-free at 1 mg/mL.

 

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