CD11b Monoclonal Mouse Antibody (ITGAM/3340)
CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin aM combines with the Integrin ‘2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin aM/’2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part of a heterodimer that consists of CD11b andCD18. It also modulates the uptake of complement-coated particles within the cell. It is commonly used as a microglial marker in tissues derived from the nervous system.
Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. See the CF® Dye Brochure for more information. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Catalog Number Key for Primary Antibody Conjugates
|Antibody # prefix||Conjugation||Ex/Em (nm)||Laser line||Detection channel||Dye Features|
|BNC04||CF®405S||404/431||405||DAPI (microscopy), AF405||CF®405S Features|
|BNC88||CF®488A||490/515||488||GFP, FITC||CF®488A Features|
|BNC68||CF®568||562/583||532, 561||RFP, TRITC||CF®568 Features|
|BNC94||CF®594||593/614||561||Texas Red®||CF®594 Features|