CD6 Monoclonal Mouse Antibody (SPV-L14)
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Product Description
CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.
References
Note: References for this clone sold by other suppliers may be listed for expected applications.
- PNAS USA (1987) 84: 3861-3865. (Flow, surface; IF)
- J Inv Dermatol (1994) 102(6): 833-837. (Flow, surface)
- J Immunol (2006) 177:1152-1159. (functional studies)
- Nat Immunol (2014) 15(4): 384-392. (functional studies)
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