Recognizes a 100kDa glycoprotein, identified as CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA). It is a cell surface enzyme with neutral metalloendopeptidase activity, which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt’s, and follicular germinal center lymphomas, and on cells from patients with chronic myelocytic leukemia (CML). It is also expressed on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells.
Brown, B. et al., J. Natl. Canc. Inst, 55: 1281-1289 (1975). | Tran-Paterson, R. et al., Blood, 76: 775-782 (1990) | Doerken, B. et al., in Knapp, W. et. al. (eds)., Leucocyte Typing IV, Oxford Univ. Press, pp 33-34. | Lavabre-Bertrand, T., et. al., Cytometry, 18: 209-217 (1994). | Guerin S; et al. Cellular Immunology, 1997 Jan 10, 175(1):85-91. | Guerin S; et al. Faseb Journal, 1997 Apr, 11(5):376-81
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