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CD61 / Integrin Beta-3 / Platelet-Glycoprotein-IIIa Monoclonal Mouse Antibody (25E11)

Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain).

Product Attributes

Antibody number

1048

Reactivity (target)

CD61

Antibody type

Primary

Host species

Mouse

Clonality

Monoclonal

Clone

25E11

Isotype

IgM, kappa

Molecular weight

105 kDa & 90 kDa

Synonyms

BDPLT2; GP3A; GPIIIa; GT; HPA 1; HPA 4; Integrin beta-3; ITGB3; NAIT; Platelet fibrinogen receptor beta subunit; Platelet glycoprotein IIIa; PTP

Human gene symbol

ITGB3

Entrez gene ID

3690

SwissProt

P05106

Unigene

218040

Immunogen

Normal blood mononuclear cells activated by mixed lymphocyte reaction

Cellular localization

Membrane/cell surface

Species reactivity

Human

Applications

Immunofluorescence, Flow cytometry, Receptor blockade

Application notes

Immunofluorescence 0.5-1 ug/mL, Flow Cytometry 0.5-1 ug/million cells/0.1 mL, Inhibits platelet aggregation, Optimal dilution for a specific application should be determined by user

Positive control

U937, KG1a, HEL cells, and human platelets in lymph nodes or tonsils.

Shipping condition

Room temperature

Storage Conditions

Store at 2 to 8 °C, Note: store BSA-free antibodies at -10 to -35 °C

Shelf life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Regulatory status

For research use only (RUO)

Research areas

Cell adhesion

Conjugation
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Product Description

Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). The protein detectable is a complex of CD41 and CD61.The apparent molecular weight of the GPIIIa by SDS-PAGE is 105 kDa reduced and 90 kDa unreduced. Ligands are fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin. Residues 237-248 of GPIIIa or CD61 are critical in adhesive protein binding.

This antibody is available purified with BSA/azide at 200 ug/mL, or BSA/azide-free at 1 mg/mL.

References

McMichael AJ et al. (eds) Leukocyte Typing III, Oxford University Press, Oxford, 1987. | Schlossman S. et al. (eds) Leukocyte Typing V, Oxford University Press, Oxford, 1995

 

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