Monoclonal anti CD71 (TFRC/1059)

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Catalog #: BNUB1059

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Category: Primary Antibodies.

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Product Description

It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Its epitope is localized in the extracellular domain of CD71. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.

Van de Rijna M, Geurts van Kessel AHM, Kroezen V, van Agthoven AJ, Verstijnen K, Terhorst C, Hilgers J: Cytogenet Cell Genet 1983;36:525-531. | Oudermans et al. Cancer, 1986; 58:1252. | K. Moolenaar et al. Cancer research 50,1102-1106, 1990

Additional Information

Conjugation	Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP
Size	50 uL, 100 uL, 250 uL, 500 uL
Supplied As	Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA
Antibody type	Primary
Host species	Mouse
Reactivity (target)	CD71 (TFRC/1059)
Clonality	Monoclonal
Isotype	IgG2a, kappa
Clone	TFRC/1059
Molecular weight	85-95 kDa (monomer); 190 kDa (dimer)
Synonyms	Mtvr-1, p90, TFR1, TFRC transferrin receptor (p90 CD71), TRFR
Entrez gene ID	7037
SwissProt	P02786
Unigene	529618
Immunogen	Recombinant human TFRC protein
Species reactivity	Human
Applications	Flow cytometry, Immunofluorescence
Cellular localization	Cell surface
Application notes	Flow Cytometry (0.5-1 ug/million cells/0.1 mL), Immunofluorescence 1-2 ug/mL, Optimal dilution for a specific application should be determined by user
Positive control	CCRF-CEM, Jurkat or K-562. Human placenta or breast carcinoma.

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

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