This Ab reacts with the rod domain of human cytokeratin 19 (CK19), a polypeptide of 40kDa. CK19 is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.
Morton JP et. al. Am J Pathol 172:1081-7 (2008). | Olofsson MH et. al. Clin Cancer Res 13:3198-206 (2007). | Aleksic T et. al. Gut 56:227-36 (2007). | Nightingale J et. al. J Am Soc Nephrol 15:21-32 (2004). | Lewis BC et. al. Genes Dev 17:3127-38 (2003). | Bartek J et. al. J Cell Sci 75:17-33 (1985) | Bartek J et. al. Int J Cancer 36:299-306 (1985)
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