Monoclonal anti PLAP (Placental Alkaline Phosphatase) (PL8 F6)

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Catalog #: BNUB0889
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Product Description

Reacts with a 70kDa membrane-bound isozyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase. Anti-PLAP reacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease.

Fishman WH, et al. Cancer Res 28:150-154, 1968. | Ho DM, et al. Cancer 70: 1577-1584, 1992. | Loke Y, et al. Int J Cancer 25:459-461, 1980. | Millan JL and Manes T. Proc Natl Acad Sci USA 85: 3024-3028, 1988. |

Additional Information


Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP


50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type


Host species


Reactivity (target)

PLAP (Placental Alkaline Phosphatase) (PL8-F6)






IgG2b, kappa

Molecular weight

70 kDa

Entrez gene ID





Purified human PLAP protein



Species reactivity



Immunohistology (frozen), Flow cytometry, Immunofluorescence, Immunohistology (formalin)

Cellular localization

Cytoplasmic and cell surface

Application notes

Flow Cytometry (0.5-1 ug/million cells/0.1 mL), Immunofluorescence 0.5-1 ug/mL, Immunohistology Frozen & formalin-fixed 0.25-0.5 ug/mL for 30 minutes at RT, No special pretreatment is required for the immunohistochemical staining of formalin-fixed tissues., Optimal dilution for a specific application should be determined by user

Positive control

HepG2 cells. Placenta or seminoma

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

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