Monoclonal anti Thyroglobulin (6E1.)

BNUB0051-0
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Product Description

Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.

Ossendorp FA, et. al. Journal of Immunological Methods, 1989, 120(2):191-200. | Bellet, D, et al. J Clin Endocrin Metab 1983;56:530-533 | Heffess CS et al. Cancer. 2002;95(9):1869-78 | Judkins AR et al. Hum Pathol. 1999;30(11):1373-6 |

Additional Information

Conjugation

Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP

Size

50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type

Primary

Host species

Mouse

Reactivity (target)

Thyroglobulin (6E1.)

Clonality

Monoclonal

Clone

6E1.

Isotype

IgG1, kappa

Molecular weight

660 kDa (Dimeric Form)

Synonyms

AITD3, hTG, TDH3, Tg, Tgn

Entrez gene ID

7038

SwissProt

P01266

Immunogen

Human thyroid follicular cells

Unigene

654591

Species reactivity

Human

Applications

Flow cytometry, Immunohistology (formalin)

Cellular localization

Cytoplasmic, Secreted

Application notes

30 min at RT, Does not react with mouse or rat; others not known, Flow Cytometry (0.5-1 ug/million cells/0.1 mL), Immunohistology formalin-fixed 0.1-0.2 ug/mL, Optimal dilution for a specific application should be determined by user, Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes

Positive control

Thyroid

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

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