ACTH Monoclonal Mouse Antibody (CLIP/1407)
ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. See the CF® Dye Brochure for more information. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Catalog number key for antibody number 1407, Anti-ACTH (CLIP/1407)
Catalog Number Key for Primary Antibody Conjugates
|Antibody # prefix||Conjugation||Ex/Em (nm)||Laser line||Detection channel||Dye Features|
|BNC04||CF®405S||404/431||405||DAPI (microscopy), AF405||CF®405S Features|
|BNC88||CF®488A||490/515||488||GFP, FITC||CF®488A Features|
|BNC68||CF®568||562/583||532, 561||RFP, TRITC||CF®568 Features|
|BNC94||CF®594||593/614||561||Texas Red®||CF®594 Features|