Neuroscience

A cell-permeable dye that exhibits enhanced fluorescence upon binding to amyloid fibrils, and has been used in histology and for protein characterization.

Congo Red has been used in microscopy for staining elastic fibers and bacteria. Amyloid protein, an abnormal protein aggregate associated with various pathologies, is commonly detected in tissue with Congo Red.

A fixable red fluorescent nerve terminal probe that is spectrally identical to SynaptoRed™ C2 (also called FM®4-64).

Far-red fluorescent probe with high affinity for Aβ plaques/aggregates, that can be used for fluorescent staining of brain sections and in vivo detection of Aβ_1-42 aggregates in small animals.

HM1-43 is a fixable, activity-dependent fluorescent nerve terminal probe.

Biotin ethylenediamine in free base form. White solid soluble in DMSO.

Biotin ethylenediamine iodoacetamide is readily coupled to thiols.

Biotin ethylenediamine, hydrobromide (N-(5-(6-((biotinoyl)amino)hexanoyl)amino)pentylmaleimide) is identical to Neurobiotin™, a useful anterograde and transneuronal tracer.

PathoGreen™ Histofluorescent Stain is an anionic green fluorescent dye functionally similar to Fluoro-Jade dyes. These dyes stain degenerating neurons and their processes after exposure to a variety of neurotoxic insults in brain sections and cultured neurons.

Hydroxystilbamidine (also called Fluoro-Gold™) has been used extensively as a retrograde tracer for neurons and also a histochemical stain.

SGC5 is a coumarin styryl dye that binds to membranes in a manner similar to the FM® dyes. It becomes highly fluorescent upon insertion into lipid bilayers.

SGC3 is a coumarin styryl dye that binds to membranes in a manner similar to the FM® dyes. It becomes highly fluorescent upon insertion into lipid bilayers.

AM3-25 is a lipophilic styryl dye that has an amine group at the hydrophilic head. The amine group reacts with formaldehyde or glutaldehyde to make the dye fixable.

SynaptoGreen™ C5 is similar to SynaptoGreen™ C4 (70020), except that the lipophilic tail is one carbon longer.

SynaptoGreen™ C18 (equivalent to FM®3-25) is a membrane stain with a chemical structure similar to other nerve terminal dyes, except that it has the longest lipophilic tail (C18). Because of its large size, it is used as a control for ion channel permeability of nerve terminal dyes.

SynaptoGreen™ C1 has the shortest (one-carbon) lipophilic tail and is the most water soluble of the nerve terminal dye series. Thus it is expected to have the slowest on-rate and the fastest off-rate among the SynaptoGreen™ dyes.