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CD147 Monoclonal Mouse Antibody (CB43)

CD147 is a transmembrane glycoprotein of the immunoglobulin superfamily.

Product Attributes

Antibody number

0363

Reactivity (target)

CD147

Antibody type

Primary

Host species

Mouse

Clonality

Monoclonal

Clone

CB43

Isotype

IgM

Molecular weight

35 kDa (non-reduced); 40 kDa (reduced)

Human gene symbol

BSG

Entrez gene ID

682

SwissProt

P35613

Unigene

501293

Immunogen

Native human leucocytes

Cellular localization

Membrane/cell surface

Species reactivity

Human

Applications

Immunofluorescence, Flow cytometry

Application notes

Immunofluorescence 0.5-1 ug/mL, Flow Cytometry 0.5-1 ug/million cells/0.1 mL, Optimal dilution for a specific application should be determined by user

Positive control

HSB2 cells. Renal Cell, Ovarian carcinoma or Melanoma

Shipping condition

Room temperature

Storage Conditions

Store at 2 to 8 °C, Note: store BSA-free antibodies at -10 to -35 °C

Shelf life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Regulatory status

For research use only (RUO)

Research areas

Cancer, Developmental biology

Conjugation
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Product Description

CD147 is a transmembrane glycoprotein of the immunoglobulin superfamily. It is expressed more intensely on thymocytes than on mature peripheral blood T cells. CD147 is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. CD147 is involved in the regulation of matrix remodeling at the epidermal-dermal interface. It stimulates the production of interstitial collagenase, gelatinase A, stromelysin-1 and various metalloproteinases (MMPs) by fibroblasts. These enzymes, which are typically increased during tissue degradation and wound healing, are important factors in cancer invasion and metastasis.

This antibody is available purified with BSA/azide at 200 ug/mL, or BSA/azide-free at 1 mg/mL.

References

Kirsch AH et. al. Tissue Antigens. 1997 Aug;50(2):147-52

 

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