Monoclonal anti Cytokeratin, multi (KRT/457)

BNUB0457-0
BNUB0457-1
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Catalog #: BNUB0457
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Product Description

Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, including 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 53kDa (CK13) and 45kDa (CK18). This is a broad-spectrum antibody, which has been reported to differentiate epithelial tumors from non-epithelial tumors. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

Bartek J et. al. J Pathol, 1991, 164(3):215-24. ,Kasper M. Histochemistry, 1991, 95(6):613-20

Additional Information

Conjugation

Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP

Size

50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type

Primary

Host species

Mouse

Reactivity (target)

Cytokeratin, multi (KRT/457)

Clonality

Monoclonal

Clone

KRT/457

Isotype

IgG1

Molecular weight

Multiple

Synonyms
Entrez gene ID

3851 (CK4); 3852 (CK5); 3853 (CK6A); 3854 (CK6B); 286887 (CK6C); 3856 (CK8); 3858 (CK10); 3860 (CK13); 3875 (CK18) (Human)

SwissProt

P02538 (CK6A); P04259 (CK6B); P13647 (CK5); P19013 (CK4); P48668 (CK6C)

Immunogen

Keratin-enriched preparation from cultured human epithelial cells

Species reactivity

Cow, Frog, Goat, Guinea Pig, Human, Monkey, Mouse, Pig, Rat

Applications

Flow cytometry, Immunofluorescence, Western

Cellular localization

Cytoplasmic

Application notes

Flow Cytometry (0.5-1 ug/million cells/0.1 mL), Immunofluorescence 0.5-1.0 ug/mL, Western blotting 0.5-1.0 ug/mL

Positive control

A431 cells, Skin, Colon carcinoma

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

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