Monoclonal anti Cytokeratin, multi (C11)

BNUB0393-0
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Product Description

This MAb recognizes cytokeratin 4, 5, 6, 8, 10, 13, and 18. This is a broad-spectrum antibody, which has been reported to differentiate epithelial tumors from non-epithelial tumors. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

  1. Kovařik et al. Int.J.Cancer, Suppl. 3: 50-55, (1988).
  2. Vojtĕšek et al. Folia Biol., 35(6), 373-382, (1989).
  3. Vojtĕšek et al. Neoplasma 37(3), 333-342 (1990).
  4. Kovařik et al. J. Tumor Marker Oncol. 5, 219 (1990).
  5. Lane EB; Alexander CM. Seminars in Cancer Biology, 1990, 1:165-79.

Additional Information

Conjugation

Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP

Size

50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type

Primary

Host species

Mouse

Reactivity (target)

Cytokeratin, multi (C11)

Clonality

Monoclonal

Clone

C11

Isotype

IgG1

Molecular weight

Multiple

Entrez gene ID

3851 (CK4); 3852 (CK5); 3853 (CK6A); 3854 (CK6B); 286887 (CK6C); 3856 (CK8); 3858 (CK10); 3860 (CK13); 3875 (CK18)

SwissProt

P19013 (CK4); P13647 (CK5); P02538 (CK6A); P04259 (CK6B); P48668 (CK6C); P05787 (CK8); P13645 (CK10); P13646 (CK13); P05783 (CK18)

Immunogen

Keratin-enriched preparation from cultured human A431

Species reactivity

Cow, Frog, Goat, Guinea Pig, Human, Marmoset, Mouse, Pig, Rat

Applications

Flow cytometry, Immunofluorescence, Western

Cellular localization

Cytoplasmic

Application notes

Flow Cytometry (0.5-1 ug/million cells/0.1 mL), Immunofluorescence 0.5-1.0 ug/mL, Immunohistology (Formalin-fixed) (0.5-1.0ug/ml for 30 min at RT), Optimal dilution for a specific application should be determined., Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes, Western blotting 0.5-1.0 ug/mL

Positive control

A431 cells, Skin, Colon carcinoma

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

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