Monoclonal anti EGFR (H9B4)

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Catalog #: BNUB0642
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Product Description

This MAb reacts with a cytoplasmic domain of EGFR. EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin & epiregulin.

Bjorge JD et. al. Journal of Biological Chemistry, 1987, 262(14):6615-22

Additional Information

Conjugation

Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP

Size

50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type

Primary

Host species

Mouse

Reactivity (target)

EGFR (H9B4)

Clonality

Monoclonal

Clone

H9B4

Isotype

IgG1, kappa

Molecular weight

~170 kDa (wild type) and ~145 kDa (vIII variant)

Synonyms

Erbb1; ERBB1; Errp; HER1; mENA; PIG61; Proto-oncogene c-ErbB-1; Receptor Tyrosine Protein Kinase; ErbB1; Urogastrone; wa2; Wa5

Entrez gene ID

1956

SwissProt

P00533

Immunogen

Purified EGFR from A431 cells.

Unigene

488293

Species reactivity

Human

Applications

Immunoprecipitation, Western

Cellular localization

Cell surface

Application notes

Does not react with mouse or rat; others not known, Immunoprecipitation 1-2 ug/500 ug protein lysate,Western blotting 0.5-1.0 ug/mL for 2 hours at RT, Optimal dilution for a specific application should be determined by user

Positive control

A431 cells, Breast or Bladder cancer

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

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