This antibody reacts with the extracellular domain of EGFR and blocks the EGF/TGF??induced activation. It also blocks tumor growth in vivo. It is excellent for purification of EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin and epiregulin.
Kudlow JE et. al. Journal of Biological Chemistry, 1986, 261(9):4134-8. | Bjorge JD et. al. Journal of Biological Chemistry, 1989, 264(7):4021-7. | Bjorge JD et. al. Journal of Biological Chemistry, 1987, 262(14):6615-22
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