Monoclonal anti Progesterone Receptor (PR501)

BNUB0501-0
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Product Description

This MAb is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81kDa) and PR-B (116kDa). Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than ER alone.

Press M, et al. Steroids. 2002 Aug; 67(9):799-813. | Mote P, et al. J Clin Pathol., 2001; 54: 624-630

Additional Information

Conjugation

Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP

Size

50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type

Primary

Host species

Mouse

Reactivity (target)

Progesterone Receptor (PR501)

Clonality

Monoclonal

Clone

PR501

Isotype

IgG1, kappa

Molecular weight

PR-A (81 kDa) and PR-B (116 kDa).

Synonyms

NR3C3, Nuclear receptor subfamily 3 group C member 3, PGR, PR, PRA, PRB, Progesterone receptor form A, Progesterone receptor form B

Entrez gene ID

5241

SwissProt

P06401

Immunogen

Recombinant human Progesterone Receptor protein

Unigene

2905

Species reactivity

Human

Applications

Immunohistology (formalin), Western

Cellular localization

Nucleus

Application notes

Immunohistology formalin-fixed 0.5-1 ug/mL, Optimal dilution for a specific application should be determined by user, Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes, Western blotting 0.5-1 ug/mL for 2 hours at Room Temp

Positive control

T47-D Cells or Breast Cancers.

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

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