This MAb is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81kDa) and PR-B (116kDa). Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than ER alone. It is excellent for immunohistochemical staining of formalin/paraffin tissues.
| Conjugation | Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP |
|---|---|
| Size | 50 uL, 100 uL, 250 uL, 500 uL |
| Supplied As | Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA |
| Antibody type | Primary |
| Host species | Mouse |
| Reactivity (target) | Progesterone Receptor (PR484) |
| Clonality | Monoclonal |
| Clone | PR484 |
| Isotype | IgG1, kappa |
| Molecular weight | PR-A (81 kDa) and PR-B (116 kDa). |
| Synonyms | NR3C3, Nuclear receptor subfamily 3 group C member 3, PGR, PR, PRA, PRB, Progesterone receptor form A, Progesterone receptor form B |
| Entrez gene ID | 5241 |
| SwissProt | P06401 |
| Immunogen | Recombinant human Progesterone Receptor protein |
| Unigene | 2905 |
| Species reactivity | Human |
| Applications | Immunohistology (formalin) |
| Cellular localization | Nucleus |
| Application notes | Immunohistology formalin-fixed 0.5-1 ug/mL for 30 min at RT, Optimal dilution for a specific application should be determined by user, Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes |
| Positive control | T47-D Cells or Breast Cancers. |
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