Support & Resources

+1

Staurosporine

Staurosporine is a potent and cell-permeable inhibitor of a wide variety of protein kinases by competing for the ATP binding site.

Product Attributes

CAS number

62996-74-1

Molecular weight

466.20

Storage Conditions

Store at -10 to -35 °C, Protect from light, Desiccate

Toxin

Alkaloid Toxin

Molecular Formula: C28H26N4O3

Note: Due to operating restrictions related to our COVID-19 response, primary antibody conjugates of R-PE, APC, PerCP, HRP, or AP are temporarily unavailable. All other antibody options are still available. We apologize for the inconvenience. Please see our easy-to-use Mix-n-Stain™ Antibody Labeling Kits for labeling antibodies with R-PE, APC, tandem dyes, and enzymes.
Size
Catalog #
price
Qty
100 ug
Clear selection
Add to wishlist
ADD TO CART
(Please select quantity above )

Wishlist updated! View wishlist

Shipping, Handling & Tax (CA only) not included in price. Learn more

Tax is assessed in the state of California. All fees will be calculated during checkout based on your shipping information and are subject to change.

SPECIAL - Order 5 or more and receive 10% off.

Request a Bulk Quote

Protocols
SDS

Product Description

Staurosporine inhibits a wide variety of protein kinases by competing for the ATP binding site. It is a potent and cell-permeable competitive inhibitor for protein kinase C (IC50 = 0.7 nM), protein kinase A (IC50 = 7 nM), and protein kinase G (IC50 = 8.5 nM) (1,2). Staurosporine induces apoptosis in human neuroblastoma cells and chick embryonic neurons (3,4).

  • Cell-permeable inhibitor of protein kinases
  • Competitive inhibition at the ATP binding site
  • Soluble in DMSO or ethanol

References

1. Biochem Biophys Res Commun. 158, 105 (1989), DOI: 10.1016/S0006-291X(89)80183-4
2. Biochem Biophys Res Commun. 135, 397 (1986), DOI: 10.1016/0006-291X(86)90008-2
3. Neuropharmacology 36, 811 (1997), DOI: s0028-3908(97)00030-0
4. J. Neurochem. 66, 1418 (1996), DOI: 10.1046/j.1471-4159.1996.66041418.x

 

You may also like…