Cholera Toxin Subunit B CF® Dye Conjugates
Binds GM1 ganglioside in lipid rafts and is used as a retrograde neuronal tracer for live imaging or on fixed cells.
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Product Description
Cholera toxin B subunit is used for tract-tracing in neurological research, targeting GM1 ganglioside binding and retrograde transport.
- Choice of 11 bright & photostable CF® Dyes from green to near-infrared
- Fluorescent lipid raft markers and retrograde neuronal tracers for live imaging or on fixed cells
Cholera toxin is the symptom-causing toxin produced by the bacteria Vibrio cholerae during cholera infection. The toxin is composed of two subunits, A and B. Subunit A is the toxic enzymatic subunit present in one copy per toxin. Cholera toxin subunit B (CT-B) is the receptor binding subunit that is found as a pentamer in each toxin and is relatively non-toxic, making it useful for cell biological studies. CT-B has been used as a neuronal tracer and has also been shown to bind to GM1 gangliosides that are found in lipid rafts on the surface of mammalian cells. Therefore, fluorescently labeled conjugates of CT-B have been used as lipid raft markers and endocytic tracers for live imaging or on fixed cells.
Superior CF® Dyes
Biotium’s next-generation CF® Dyes were designed to be highly water-soluble with advantages in brightness and photostability compared to Alexa Fluor®, DyLight®, and other fluorescent dyes. Learn more about CF® Dyes.
CF® Dye Cholera Toxin Conjugates
Conjugation | Ex/Em | Size | Catalog No. | Dye Features |
---|---|---|---|---|
CF®405M | 408/452 nm | 100 ug | 00068 | CF®405M Features |
CF®488A | 490/515 nm | 100 ug | 00070 | CF®488A Features |
CF®532 | 527/558 nm | 100 ug | 00074 | CF®532 Features |
CF®543 | 541/560 nm | 100 ug | 00075 | CF®543 Features |
CF®568 | 562/583 nm | 100 ug | 00071 | CF®568 Features |
CF®594 | 593/614 nm | 100 ug | 00072 | CF®594 Features |
CF®633 | 630/650 nm | 100 ug | 00077 | CF®633 Features |
CF®640R | 642/662 nm | 100 ug | 00073 | CF®640R Features |
CF®647 | 650/665 nm | 100 ug | 00069 | CF®647 Features |
CF®660R | 663/682 nm | 100 ug | 00078 | CF®660R Features |
CF®680R | 680/701 nm | 100 ug | 00079 | CF®680R Features |
References
CF®568 Cholera Toxin (00071)
Nature (2016) 529, 408–412. https://doi.org/10.1038/nature16516
Nature (2017) 546, 492–497. https://doi.org/10.1038/nature22818
Download a list of CF® dye references.