A potent neurotoxin that is an inhibitor for the motor endplate acetylcholine receptor (Kd = 1 nM to 1 pM). It binds at the neuromuscular junction with high affinity and is often used to study neuromuscular junctions by blocking cholinergic receptors. The toxin also blocks α7 receptors, located in the central and peripheral nervous systems. The biotin conjugate can be subsequently labeled with anti-biotin antibodies, avidin, or streptavidin for signal amplification.
- A polypeptide snake toxin
- Blocks and inhibits cholinergic receptors
- Biotinylated for avidin or streptavidin reactivity and signal amplification
- White solid soluble in water
Biotinylated α-bungarotoxin is useful in the affinity column isolation of the nicotinic AChR using an avidin or streptavidin agarose (1). Nicotinic AChR labeled with biotin-XX-α-bungarotoxin can be localized using enzyme or fluorophore-labeled conjugates of avidin or streptavidin (2,3). Alpha-bungarotoxin may also be used for detection of GABA A receptor subsets in cells (4), or for labeling recombinant proteins that express the alpha-bungarotoxin binding site (BBS) epitope tag (5).
We also offer unlabeled α-bungarotoxin and CF® Dye α-Bungarotoxin conjugated to our next-generation fluorescent dyes. See our complete selection of α-Bungarotoxin Products below.
α-Bungarotoxin, CF® Dye and Other Conjugates
CF is a registered trademark of Biotium, Inc. Texas Red is a registered trademark of Thermo Fisher Scientific.
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