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Tetrodotoxin

This toxin reversibly blocks the sodium channels of neurons and has been a widely used tool for mechanistic studies of neurons, skeletal muscle, and cardiac muscle cells.

Product Attributes

Format

Citrate Free, With Citrate

For live or fixed cells

For live/intact cells

Toxin

Tetrodotoxin

CAS number

4368-28-9

Molecular weight

319.28

Molecular Formula: C11H17N3O8

Format
Note: Due to operating restrictions related to our COVID-19 response, primary antibody conjugates of R-PE, APC, PerCP, HRP, or AP are temporarily unavailable. All other antibody options are still available. We apologize for the inconvenience. Please see our easy-to-use Mix-n-Stain™ Antibody Labeling Kits for labeling antibodies with R-PE, APC, tandem dyes, and enzymes.
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Product Description

Tetrodotoxin (TTX) is potent neurotoxin that reversibly binds and blocks sodium channels to disrupt the action potential and inhibit the firing of neurons. It is a widely used tool to study the mechanism of action of neurons, skeletal muscle cells, and cardiac muscle cells.

  • Reversibly binds and blocks voltage-gated sodium channels
  • Available with citrate or citrate-free
  • Tetrodotoxin with citrate is water soluble

Tetrodotoxin citrate-free can be dissolved in slightly acidic buffer. Tetrodotoxin with citrate can be dissolved in water to obtain TTX in pH 4.8 citrate buffer.

Chemical Structure:

References

1. Neurocomputing. 70, 10 (2007), DOI: 10.1016/j.neucom.2006.10.135
2. Frontiers in Behavioral Neuroscience 4, 21 (2010). DOI: 10.3389/fnbeh.2010.00021
3. J Neuroscience 30, 32 (2010), DOI: 10.1523/JNEUROSCI.1818-10.2010
4. J Neurophysiol 122, 4 (2019), DOI: 10.1152/jn.00038.2019

 

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