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α-Bungarotoxin

A high affinity inhibitor of the nicotinic acetylcholine receptor in the neuromuscular junction. Blocks acetylcholine activity at the postsynaptic membrane.

Product Attributes

Toxin

Alpha-bungarotoxin

CAS number

11032-79-4

Molecular weight

7984

For live or fixed cells

For fixed cells, For live/intact cells

Cell permeability

Membrane impermeant

Storage Conditions

Store at -10 to -35 °C, Protect from light

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Technology

Note: Due to operating restrictions related to our COVID-19 response, primary antibody conjugates of R-PE, APC, PerCP, HRP, or AP are temporarily unavailable. All other antibody options are still available. We apologize for the inconvenience. Please see our easy-to-use Mix-n-Stain™ Antibody Labeling Kits for labeling antibodies with R-PE, APC, tandem dyes, and enzymes.
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Product Description

A potent neurotoxin that is an inhibitor for the motor endplate acetylcholine receptor (Kd = 1 nM to 1 pM). It binds at the neuromuscular junction with high affinity and is often used to study neuromuscular junctions by blocking cholinergic receptors. Alpha-bungarotoxin may also be used for detection of GABA A receptor subsets in cells (1), or for labeling recombinant proteins that express the alpha-bungarotoxin binding site (BBS) epitope tag (2).

  • A polypeptide snake toxin
  • Blocks and inhibits cholinergic receptors
  • White solid soluble in water

Also see our Fluorescent α-Bungarotoxins and Biotin α-Bungarotoxin which can can be used for labeling of nicotinic acetylcholine receptors at neuromuscular junctions in tissue sections. See our complete selection of α-Bungarotoxins below.

α-Bungarotoxin, CF® Dye and Other Conjugates

ConjugationEx/EmSizeCatalog No.Dye Features
UnconjugatedN/A1 mg00010-1
Biotin-XXN/A0.5 mg00017
CF®405S404/431 nm100 ug00002-100ugCF®405S Features
0.5 mg00002
CF®488A490/515 nm100 ug00005-100ugCF®488A Features
0.5 mg00005
CF®543 541/560 nm100 ug00026-100ugCF®543 Features
0.5 mg00026
CF®555555/565 nm100 ug00018-100ugCF®555 Features
0.5 mg00018
CF®568562/583 nm100 ug00006-100ugCF®568 Features
0.5 mg00006
CF®594596/614 nm100 ug00007-100ugCF®594 Features
0.5 mg00007
CF®633630/650 nm100 ug00009-100ugCF®633 Features
0.5 mg00009
CF®640R642/662 nm100 ug00004-100ugCF®640R Features
0.5 mg00004
CF®680R680/701 nm100 ug00003-100ugCF®680R Features
0.5 mg00003
Fluorescein
(FITC)
494/518 nm0.5 mg00011
10 x 50 ug00013
Tetramethylrhodamine
(TRITC)
553/577 nm0.5 mg00012
10 x 50 ug00014
Sulforhodamine-101
(Texas Red®)
593/613 nm0.5 mg00015
10 x 50 ug00016

 

CF is a registered trademark of Biotium, Inc. Texas Red is a registered trademark of Thermo Fisher Scientific.

References

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  2. Meth. Enzymol., 521, (2013), DOI: 10.1016/B978-0-12-391862-8.00006-5
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  6. Front Cell Dev Biol., 8, 15, (2020), DOI: 10.3389/fcell.2020.00015
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  9. Biochemistry (Mosc.), 4, 1085, (2019), DOI: 10.1134/S0006297919090116
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  12. Cell Mol Neurobiol, 37, 1443, (2017), DOI: 10.1007/s10571-017-0475-3
  13. Neuroscience, 174, 234, (2011), DOI: 10.1016/j.neuroscience.2010.11.016
  14. Am J of Pathol, 177, 2509 (2010), DOI: 10.2353/ajpath.2010.100243
  15. Cell Tissue Biol, 4, 258, (2010), DOI: 10.1134/S1990519X10030077
  16. Neuroscience, 174, 234, (2009), DOI: 10.1016/j.neuroscience.2010.11.016
  17. J Cell Biol, 150, 1385, (2000), DOI: 10.1083/jcb.150.6.1385
  18. Neuron, 23, 675, (1999), DOI: 10.1016/s0896-6273(01)80027-1
  19. Neuron, 12, 167, (1994), DOI: 10.1016/0896-6273(94)90161-9
  20. J Cell Biol, 125, 661, (1994), DOI: 10.1083/jcb.125.3.661
  21. J Biol Chem, 268, 25108, (1993), PMID: 8227074
  22. Muscle Nerve, 5, 140, (1982), DOI: 10.1002/mus.880050211
  23. PNAS 77, 4823, (1980), DOI: 10.1073/pnas.77.8.4823
  24. Science, 196, 540, (1977), DOI: 10.1126/science.850796
 

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