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Transferrin (human) CF® Dye Conjugates

Transferrin is a glycoprotein with homologous N-terminal and C-terminal iron-binding domains that binds up to two Fe(III) atoms for delivery to vertebrate cells through receptor-mediated endocytosis.

Product Attributes

Cellular localization

Membrane/vesicular

For live or fixed cells

For live/intact cells

Assay type/options

Real-time imaging

Cell permeability

Membrane impermeant

Fixation options

Fix after staining (formaldehyde), Permeabilize after staining, Fix before staining (formaldehyde)

Colors

Green, Orange, Red, Far-red, Near-infrared

Conjugation
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1 mg
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Product Description

Transferrin is a glycoprotein with homologous N-terminal and C-terminal iron-binding domains that binds up to two Fe(III) atoms for delivery to vertebrate cells through receptor-mediated endocytosis. After binding to its receptor on the cell surface, transferrin is rapidly internalized by invagination of clathrin-coated pits with formation of endocytic vesicles, the acidic environment favors dissociation of iron from the transferrin-receptor complex. Following the release of iron, the apotransferrin is recycled to the plasma membrane where it is released from its receptor to scavenge more iron. Human transferrin is labeled with our bright and photostable CF® dyes for investigation of endocytosis by microscopy. Download the product protocol to view the full list of conjugates and their excitation/emission wavelengths.

It’s available with the following CF® dyes: CF®488A, CF®543, CF®568, CF®594, CF®640R, CF®680R, and CF®750.

References

Download a list of CF® dye references.

 

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    Transferrin (human) CF® Dye Conjugates

    Transferrin is a glycoprotein with homologous N-terminal and C-terminal iron-binding domains that binds up to two Fe(III) atoms for delivery to vertebrate cells through receptor-mediated endocytosis.