Support & Resources



CF® dye with TCO (trans-cyclooctene) groups react with tetrazine-labeled molecules via copper-free click chemistry.

Product Attributes

Chemical reactivity (reacts with)


Functional group

TCO (trans-cyclooctene)

Storage Conditions

Store at -10 to -35 °C, Protect from light

Don’t see what you’re looking for? Contact us for more conjugation options.
Note: Due to operating restrictions related to our COVID-19 response, primary antibody conjugates of R-PE, APC, PerCP, HRP, or AP are temporarily unavailable. All other antibody options are still available. We apologize for the inconvenience. Please see our easy-to-use Mix-n-Stain™ Antibody Labeling Kits for labeling antibodies with R-PE, APC, tandem dyes, and enzymes.
Catalog #
1 mg
Clear selection
Add to wishlist
(Please select quantity above )

Wishlist updated! View wishlist

Shipping, Handling & Tax (CA only) not included in price. Learn more

Tax is assessed in the state of California. All fees will be calculated during checkout based on your shipping information and are subject to change.

SPECIAL - Order 5 or more and receive 10% off.

Request a Bulk Quote

Product Description

CF® dye with TCO group reacts with tetrazine containing molecules via copper-free click chemistry. Copper-free bioorthogonal reactions are useful for labeling live cells, or when there are concerns about native protein function loss with copper in cell extracts. Membrane-permeant CF® dye methyltetrazine options are also available for intracellular labeling reactions.

Available CF® dye TCO derivatives: CF®488A, CF®532, CF®555, CF®568, CF®594, CF®640R, CF®647, CF®680, and CF®680R including membrane-permeant CF®500, and CF®650 TCO.

  • Fluorescent labeling of tetrazine groups on target molecules via copper-free bioorthonal chemistry.
  • Membrane-impermeant and membrane-permeant forms for  surface or intracellular labeling of live cells or cell extracts.
  • Bright, photostable and water-soluble CF® dyes are excellent options for fluorescent labeling.


We also offer CF® dye tetrazine and CF® dye methyltetrazine.

Superior CF® Dyes

Biotium’s next-generation CF® dyes were designed to be highly water-soluble with advantages in brightness and photostability compared to Alexa Fluor®, DyLight®, and other fluorescent dyes. Learn more about CF® Dyes. For more information download the CF® Dye Brochure.

CF Dye TCO: Product & SKU Summary

CF®488A TCOCF®488A490/515 nm1 mg96040Purchase 96040
CF®500 TCOCF®500500/510 nm1 mg96041Purchase 96041
CF®532 TCOCF®532527/558 nm1 mg96042Purchase 96042
CF®555 TCOCF®555555/565 nm1 mg96043Purchase 96043
CF®568 TCOCF®568562/583 nm1 mg96044Purchase 96044
CF®594 TCOCF®594593/614 nm1 mg96045Purchase 96045
CF®640R TCOCF®640R642/662 nm1 mg96046Purchase 96046
CF®647 TCOCF®647650/665 nm1 mg96047Purchase 96047
CF®650 TCOCF®650650/670 nm1 mg96048Purchase 96048
CF®680 TCOCF®680681/698 nm1 mg96051Purchase 96051
CF®680R TCOCF®680R680/701 nm1 mg96049Purchase 96049