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CF® Dye Methyltetrazine

CF® dye with methyltetrazine reacts with cyclooctene (TCO, methylcyclopropene) labeled molecules via copper-free click chemistry.

Product Attributes

Chemical reactivity (reacts with)

Cyclooctene (TCO, methylcyclopropene) groups

Functional group


Storage Conditions

Store at -10 to -35 °C, Protect from light

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Catalog #
1 mg
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Product Description

CF® dye with a methyltetrazine group react with cyclooctene (TCO, methylcyclopropene) containing molecules via copper-free click chemistry. This copper-free bioorthogonal reaction is useful for labeling live cells, or when there are concerns about native protein function loss with copper in cell extracts. Membrane-permeant CF® dye methyltetrazine options are also available for intracellular labeling reactions.

Available CF® dye methyltetrazine derivatives: CF®488A, CF®532, CF®555, CF®568, CF®594, CF®640R, CF®647, CF®680, and CF®680R including membrane-permeant CF®500, and CF®650 methyltetrazine.

  • Fluorescent labeling of cyclooctene (TCO, methylcyclopropene) groups on target molecules via copper-free bioorthonal chemistry.
  • Membrane-impermeant and membrane-permeant forms for  surface or intracellular labeling of live cells or cell extracts.
  • Bright, photostable and water-soluble CF® dyes are excellent options for fluorescent labeling.


CF® dye methyltetrazines have improved chemical stability compared to CF® dye tetrazines. We also offer CF® dye TCO.

Superior CF® Dyes

Biotium’s next-generation CF® dyes were designed to be highly water-soluble with advantages in brightness and photostability compared to Alexa Fluor®, DyLight®, and other fluorescent dyes. Learn more about CF® Dyes. For more information download the CF® Dye Brochure.

CF Dye Methyltetrazine: Product & SKU Summary

CF®488A MethyltetrazineCF®488A490/515 nm1 mg96028Purchase 96028
CF®500 MethyltetrazineCF®500500/510 nm1 mg96029Purchase 96029
CF®532 MethyltetrazineCF®532527/558 nm1 mg96030Purchase 96030
CF®555 MethyltetrazineCF®555555/565 nm1 mg96031Purchase 96031
CF®568 MethyltetrazineCF®568562/583 nm1 mg96032Purchase 96032
CF®594 MethyltetrazineCF®594593/614 nm1 mg96033Purchase 96033
CF®640R MethyltetrazineCF®640R642/662 nm1 mg96034Purchase 96034
CF®647 MethyltetrazineCF®647650/665 nm1 mg96035Purchase 96035
CF®650 MethyltetrazineCF®650650/670 nm1 mg96036Purchase 96036
CF®680 MethyltetrazineCF®680681/698 nm1 mg96039Purchase 96039
CF®680R MethyltetrazineCF®680R680/701 nm1 mg96037Purchase 96037