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Spermine NONOate

Releases nitric oxide by spontaneously dissociating in a pH-dependent manner and is useful for reliable and controllable NO generation in solution.

Product Attributes

CAS number

136587-13-8

Molecular weight

262.4

Storage Conditions

Store at -10 to -35 °C or below, Desiccate

Molecular Formula: C10H26N6O2

Note: Due to operating restrictions related to our COVID-19 response, primary antibody conjugates of R-PE, APC, PerCP, HRP, or AP are temporarily unavailable. All other antibody options are still available. We apologize for the inconvenience. Please see our easy-to-use Mix-n-Stain™ Antibody Labeling Kits for labeling antibodies with R-PE, APC, tandem dyes, and enzymes.
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Product Description

Spermine NONOate releases nitric oxide by spontaneously dissociating in a pH-dependent manner. It is useful for reliable NO generation.

  • Generate a controlled release of nitric oxide
  • Spontaneously dissociates in a pH-dependent, first-order reaction
  • White solid soluble in water

NO concentration is often assessed by measuring nitrite level using the Griess Reagent. If a variety of nitric oxide generators are needed, we offer a Nitric Oxide Generation Kit which has 10mg each of SIN-1 (00221), SNAP (00222), S-nitrosoglutathione (00223), spermine NONOate (00224), and DEA-NONOate (00225).

Molecular Structure

References

  1. J. Med. Chem 34, 3242 (1991), DOI: 10.1021/jm00115a013
  2. Cancer Res. 53, 564-567 (1993)
  3. PNAS 90, 9813 (1993), DOI: 10.1073/pnas.90.21.9813
  4. Meth Enzymol 268, 281 (1996), DOI: 10.1016/S0076-6879(96)68030-6
 

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