Support & Resources



Generate nitric oxide and form superoxides spontaneously under physiological conditions and is often used to probe the cell stress response and induce cGMP production.

Product Attributes

CAS number


Molecular weight


Storage Conditions

Store at -10 to -35 °C or below, Desiccate

Molecular Formula: C6H10N4O2

Note: Due to operating restrictions related to our COVID-19 response, primary antibody conjugates of R-PE, APC, PerCP, HRP, or AP are temporarily unavailable. All other antibody options are still available. We apologize for the inconvenience. Please see our easy-to-use Mix-n-Stain™ Antibody Labeling Kits for labeling antibodies with R-PE, APC, tandem dyes, and enzymes.
Catalog #
25 x 1 mg
50 mg
Clear selection
Add to wishlist
(Please select quantity above )

Wishlist updated! View wishlist

Shipping, Handling & Tax (CA only) not included in price. Learn more

Tax is assessed in the state of California. All fees will be calculated during checkout based on your shipping information and are subject to change.

SPECIAL - Order 5 or more and receive 10% off.

Request a Bulk Quote


Product Description

SIN-1 (Morpholinosydnonimine, hydrochloride) releases nitric oxide and forms superoxide spontaneously under physiological conditions; stimulates cGMP production;  and has been shown to be a potent vasodilator.

  • Generate nitric oxide and superoxides
  • Stimulates cyclic GMP production
  • White solid soluble in water and DMSO

Fluorescent calcium indicators and SIN-1 are often used to probe the cellular reactions to cell stress, NO, and trace intracellular calcium. It has been shown to be a potent vasodilator in vivo and in vitro and to inhibit smooth muscle cell mitogenesis and proliferation. NO concentration is often assessed by measuring nitrite level using the Griess Reagent.

If a variety of nitric oxide generators are needed, we offer a Nitric Oxide Generation Kit which has 10mg each of SIN-1 (00221), SNAP (00222), S-nitrosoglutathione (00223), spermine NONOate (00224), and DEA-NONOate (00225).

Molecular Structure:


  1. J Pharmacol Exp Ther 248, 762 (1989), J Pharmacol Exp Ther 248, 762 (1989)
  2. Nature 364, 626 (1993), DOI: 10.1038/364626a0
  3. Bioorg Med Chem Lett. 21, 6515 (2011), DOI: 10.1016/j.bmcl.2011.08.071

You may also like…

    Griess Reagent Kit

    A chemical solution that is used for absorbance-based nitrite detection in biological samples such as cell lysates or tissue perfusates.

    Nitric Oxide Generation Kit

    Various nitric oxide generators for probing biochemical and physiological functions and for controllable NO generation in solution.

    NOS Inhibitor Kit

    A collection of popular inhibitors of the nitric oxide synthase isoforms, commonly used for studies of the biochemical and physiological functions of NO.


    Generate nitric oxide and form superoxides spontaneously under physiological conditions and is often used to probe the cell stress response and stimulate calcium-independent synaptic vesicle release.

    Dihydroethidium (Hydroethidium)

    Dihydroethidium (also called hydroethidium) is the chemically reduced form of the commonly used DNA dye ethidium bromide. The probe is useful to detect oxidative activities in viable cells, including respiratory burst in phagocytes.

    Dihydrorhodamine 123

    Dihydrorhodamine 123 is the reduced form of rhodamine 123 (70010), which is a commonly used fluorescent mitochondrial dye.