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SIN-1

Generate nitric oxide and form superoxides spontaneously under physiological conditions and is often used to probe the cell stress response and induce cGMP production.

Product Attributes

CAS number

16142-27-1

Molecular weight

206.7

Storage Conditions

Store at -10 to -35 °C or below, Desiccate

Molecular Formula: C6H10N4O2

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25 x 1 mg
50 mg
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Product Description

SIN-1 (Morpholinosydnonimine, hydrochloride) releases nitric oxide and forms superoxide spontaneously under physiological conditions; stimulates cGMP production;  and has been shown to be a potent vasodilator.

  • Generate nitric oxide and superoxides
  • Stimulates cyclic GMP production
  • White solid soluble in water and DMSO

Fluorescent calcium indicators and SIN-1 are often used to probe the cellular reactions to cell stress, NO, and trace intracellular calcium. It has been shown to be a potent vasodilator in vivo and in vitro and to inhibit smooth muscle cell mitogenesis and proliferation. NO concentration is often assessed by measuring nitrite level using the Griess Reagent.

If a variety of nitric oxide generators are needed, we offer a Nitric Oxide Generation Kit which has 10mg each of SIN-1 (00221), SNAP (00222), S-nitrosoglutathione (00223), spermine NONOate (00224), and DEA-NONOate (00225).

Molecular Structure:

References

  1. J Pharmacol Exp Ther 248, 762 (1989), J Pharmacol Exp Ther 248, 762 (1989)
  2. Nature 364, 626 (1993), DOI: 10.1038/364626a0
  3. Bioorg Med Chem Lett. 21, 6515 (2011), DOI: 10.1016/j.bmcl.2011.08.071
 

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