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TMRM (Tetramethylrhodamine methyl ester, perchlorate) and TMRE are preferred dyes for quantitative measurements of membrane potentials using the Nernst equation.

Product Attributes

CAS number


Cellular localization


For live or fixed cells

For live/intact cells

Assay type/options

Real-time imaging

Cell permeability

Membrane permeant

Apoptosis/viability marker

Mitochondrial potential

Potential dependence

Mitochondrial potential-dependent




549/574 nm

Catalog #
25 mg
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Product Description

TMRM (Tetramethylrhodamine methyl ester, perchlorate) and TMRE (70016) are preferred dyes for quantitative measurements of membrane potentials using the Nernst equation. The dyes do not form aggregates in cell membranes and have minimal interaction with membrane proteins. Thus, the transmembrane distribution of the dyes is directly related to the membrane potential according to the Nernst equation. We also offer TMRE, 2 mM in DMSO.

  • λExEm (MeOH) = 548/573 nm
  • Red solid soluble in DMSO, DMF or EtOH
  • Store at 4°C and protect from light
  • C25H25ClN2O7
  • MW: 501
  • [115532-50-8]


1. Meth Cell Biol 38, 195 (1993).

2. Meth Cell Biol 30, 193 (1989).

3. Biophys J 56, 1053 (1989).

4. Biophys J 53, 785 (1988).


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