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ViaFluor® Live Cell Microtubule Stains

ViaFluor® Live Cell Microtubule Stains are cell-permeable taxol probes for imaging the microtubule cytoskeleton in live cells. Available with blue, green, or far-red fluorescence.

Product Attributes

Cellular localization

Cytoskeleton, Microtubules

Dye

ViaFluor® 405, ViaFluor® 488, ViaFluor® 647

For live or fixed cells

For live/intact cells

Assay type/options

Long term staining (24-72h)

Cell permeability

Membrane permeant

Colors

Blue, Green, Far-red

ViaFluor® Live Cell Microtubule Stains Features

  • Rapidly stain microtubules in live cells
  • No wash required
  • Choose from blue, green, or far-red fluorescence

 

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Product Description

ViaFluor® Live Cell Microtubule Stains are cell-permeable TAXOL® (paclitaxel) probes for imaging the microtubule cytoskeleton in live cells. They are simple, rapid and sensitive stains that can be imaged without a wash step.

TAXOL® binds to polymerized tubulin and stabilizes microtubules, resulting in inhibition of mitosis. However, fluorescent TAXOL® compounds like ViaFluor® Microtubule Stains are less disruptive of microtubule dynamics and cell division, presumably due to lower binding affinity of the fluorescent probe compared to TAXOL® itself. The probes can be used to stain cells for as long as 48 hours to several days. However, the probes may show cytotoxicity and cell cycle arrest with longer incubation times. ViaFluor® Live Cell Microtubule Stains cannot be fixed after staining, and cannot be used with fixed cells or tissues.

ViaFluor® Microtubule Stains are supplied as a 1000X stock solutions in DMSO. They come with a vial of 100 mM verapamil, an efflux pump inhibitor that may improve probe retention and staining in some cell types. Note that this is a higher concentration than previously supplied with the stains, to allow for the use of higher verapamil concentrations (10-100 uM). The optimal concentration of verapamil should be determined by the user for their cell type.

ViaFluor® Live Cell Microtubule Stains are available in three colors:

Catalog numberNameEx/EmFeatures
70064ViaFluor® 405 Live Cell Microtubule Stain408/452 nmBlue fluorescence for the DAPI channel
70062ViaFluor® 488 Live Cell Microtubule Stain500/515 nmGreen fluorescence for the FITC channel
70063ViaFluor® 647 Live Cell Microtubule Stain650/675 nmFar-red fluorescence for the Cy®5 channel; compatible with SIM or STED

Learn more about our other fluorescent cellular stains for nucleus, mitochondria, lysosomes, and more.

Cy5 is a registered trademark of GE Healthcare.
TAXOL is a registered trademark of Bristol-Myers Squibb.

 

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