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CA19-9 / Sialyl-Lewis A Monoclonal Mouse Antibody (121SLE)

CA19-9, a carbohydrate epitope expressed on a high MW (>400kDa) mucin glycoprotein, is a sialyl Lewisa structure which is synthesized from type 1 blood group precursor chains. It is present in individuals expressing the Lewisa and/or Lewisb blood group antigens.

Product Attributes

Antibody number

0025

Reactivity (target)

CA19-9/Sialyl-Lewisa

Antibody type

Primary

Host species

Mouse

Clonality

Monoclonal

Clone

121SLE

Isotype

IgM, kappa

Molecular weight

>400 kDa

Synonyms

CA19.9, Ovarian tumor antigen, Pancreatic tumor antigen, Sialyl Lewis a

Human gene symbol

Not Known

Entrez gene ID

Not Known

SwissProt

Not Known

Unigene

Not Known

Immunogen

Precipitin lines obtained after immuno-diffusion using MAb 116-NS-19-9 and mucins isolated from an ovarian cyst of a Lewis A B- patient (0Le).

Cellular localization

Cytoplasmic

Cell/tissue expression

Epithelial cells

Species reactivity

Human

Applications

Immunofluorescence, Immunohistology (formalin), Flow cytometry

Application notes

Immunohistology (formalin), No special pretreatment is required for the immunohistochemical staining of formalin-fixed, paraffin-embedded tissues, Immunofluorescence 0.5-1 ug/mL, Flow Cytometry 0.5-1 ug/million cells/0.1 mL

Positive control

Stomach or Colon Carcinoma

Shipping condition

Room temperature

Storage Conditions

Store at 2 to 8 °C, Note: store BSA-free antibodies at -10 to -35 °C

Shelf life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Regulatory status

For research use only (RUO)

Research areas

Cancer, Hematology

Tumor expression

Gastrointestinal cancer, Pancreatic cancer

Conjugation
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Product Description

CA19-9, a carbohydrate epitope expressed on a high MW (>400 kDa) mucin glycoprotein, is a sialyl Lewisa structure which is synthesized from type 1 blood group precursor chains. It is present in individuals expressing the Lewisa and/or Lewisb blood group antigens. In normal tissues, sialyl Lewisa antigen is present in ductal epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is greatly enhanced in serum as well as in the majority of tumor cells in gastrointestinal (GI) carcinomas, including adenocarcinomas of the stomach, intestine, and pancreas. Preoperative elevated CA19-9 levels in patients with stage I pancreatic carcinoma decrease to normal values following surgery. When used serially, CA19-9 can predict recurrence of disease prior to radiographic or clinical findings. This MAb is excellent for staining of formalin-fixed, paraffin-embedded tissues.

This antibody is available purified with BSA/azide at 200 ug/mL, or BSA/azide-free at 1 mg/mL.

References

Blood transfusion and Immunohaematology, Ph. Rouger, D Anstee and Ch. Salmon (Eds). Arnette, France 30 (5): 353-720 (1987). | Tumor Biol 19(5): 390420, (1998; TD-6 Workshop Report)

 

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