Monoclonal anti CD15 / FUT4 / Lewis x (MMA (Leu M1))

BNUB0277-0
BNUB0277-1
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Product Description

CD15 plays a role in mediating phagocytosis, bactericidal activity, and chemotaxis. It is present on >95% of granulocytes including neutrophils and eosinophils and to a lesser degree on monocytes. In addition, CD15 is expressed in Reed-Sternberg cells and some epithelial cells. CD15 antibody is very useful in the identification of Hodgkin s disease. CD15 is occasionally expressed in large cell lymphomas of both B and T phenotypes which otherwise have a quite distinct histological appearance.

Hanjan SN et. al. Clinical Immunology & Immunopathology, 1982;23(2):172-88.2. Hsu et. al. Amer J Clin Pathol 82: 29, 1984.3. Pinkus et. al. Am J Pathol 119: 244, 1985

Additional Information

Conjugation

Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP

Size

50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type

Primary

Host species

Mouse

Reactivity (target)

CD15 / FUT4 / Lewis x (MMA (Leu-M1))

Clonality

Monoclonal

Isotype

IgM, kappa

Clone

Leu-M1

Molecular weight

220 kDa

Synonyms
Entrez gene ID

2526

SwissProt

P22083

Unigene

654379

Immunogen

U937 histiocytic cell line

Species reactivity

Human

Applications

Flow cytometry, Immunofluorescence, Immunohistology (formalin)

Cellular localization

Cell surface and granular paranuclear

Application notes

Flow Cytometry 0.5-1 ug/million cells, Immunofluorescence 0.5-1 ug/mL, Immunohistology (formalin), Optimal dilution for a specific application should be determined by user, Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes

Positive control

U937 cells, Reed-Sternberg's cells in Hodgkin's lymphoma

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

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