Recognizes a protein of 52kDa-58kDa, identified as CD46 (also known as membrane cofactor protein, MCP). CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria. This MAb can be applied to test complement activation in pseudo-allergic reactions to acetylsalicylic acid and to test for measles virus infection of cells.
Kishimoto T. et al., eds. Leukocyte Typing VI, p506-509 and p1145-1146, Garland Publishing, Inc., New York and London, 1997. | Liszewski MK and Atkinson JP. Membrane cofactor protein (MCP; CD46). Isoforms differ in protection against the classical pathway of complement. J Immunol 1996, 156:4415-4421. | Blixenkrone-Moller M, et al. Role of CD46 in measles virus infection in CD46 transgenic mice. Virology 1998, 249(2):238-248 | Okada N et al. Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. Proc Natl Acad Sci U S A 1995, 92(7):2489-2493. | Kallstrom H et al. Cell signaling by the type IV pili of pathogenic Neisseria. J Biol Chem 1998, 273(34):21777-8
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