Monoclonal anti CD70 (TNFS7/1026)

BNUB1026-0
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Catalog #: BNUB1026
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Product Description

It recognizes a protein of 30kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis.

Lens, S.M., et al. 1995. CD27-CD70 interaction: unravelling its implication in normal and neoplastic B cell growth. Leuk. Lymphoma 18: 51-59

Additional Information

Conjugation

Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP

Size

50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type

Primary

Host species

Mouse

Reactivity (target)

CD70 (TNFS7/1026)

Clonality

Monoclonal

Isotype

IgG's

Clone

TNFS7/1026

Molecular weight

~30 kDa

Synonyms

CD27 ligand (CD27L); CD27LG; Ki24; Surface antigen CD70; Tumor necrosis factor (ligand) superfamily, member 7 (TNFSF7)

Entrez gene ID

970

SwissProt

P32970

Unigene

501497 & 715224

Immunogen

Recombinant human CD70 protein

Species reactivity

Human

Applications

ELISA, Immunohistology (frozen), Immunoprecipitation, Flow cytometry, Immunofluorescence

Cellular localization

Cell surface

Application notes

ELISA For coating, order Ab without BSAFlow Cytometry, Immunofluorescence 0.5-1 ug/mL, Immunohistology Frozen 0.5-1 ug/mL for 30 minutes at RT, Immunoprecipitation 0.5-1 ug/500 ug protein lysate, Optimal dilution for a specific application should be determined by user

Positive control

Raji cells. Lymph node or tonsil.

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

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