Monoclonal anti CD71 (DF1513)

BNUB0188-0
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Product Description

It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa (Workshop IV). This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.

Knapp et al. Leukocyte Typing IV, Oxford Univ Press, Nrs. M15, M15.1, M15.1.1, M15.2, M15.3.1, M15.3.3, M15.4.2, M15.4.3, M15.5.6, M15.5.7, M15.5.9, M16.1, P1.6 and B22.16

Additional Information

Conjugation

Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP

Size

50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type

Primary

Host species

Mouse

Reactivity (target)

CD71 (DF1513)

Clonality

Monoclonal

Clone

DF1513

Isotype

IgG1, kappa

Molecular weight

85-95 kDa (monomer); 190 kDa (dimer)

Synonyms

Mtvr-1, p90, TFR1, TFRC transferrin receptor (p90 CD71), TRFR

Entrez gene ID

7037

SwissProt

P02786

Immunogen

KG1 acute myeloid leukemia cell line

Unigene

529618

Species reactivity

Human

Applications

Flow cytometry, Immunofluorescence, Western

Cellular localization

Cell surface

Application notes

Flow Cytometry (0.5-1 ug/million cells/0.1 mL), Immunofluorescence 1-2 ug/mL, Optimal dilution for a specific application should be determined by user, Western blotting 0.5-1.0 ug/mL

Positive control

CCRF-CEM, Jurkat or K-562. Human placenta or breast carcinoma.

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

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