Monoclonal anti Glucose Regulated Protein 94 (GRP94) (HSP90B1/1192)

BNUB1192-0
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Catalog #: BNUB1192
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Product Description

Recognizes a protein of 94kDa, which is identified as the glucose-regulated protein 94 (grp94) and also tumor rejection antigen (gp96). Grp94 shows a high degree of sequence homology with the heat shock protein 90 (hsp90). This MAb is highly specific to grp94 and shows minimal cross-reaction with other members of the HSP90 family. Grp s are a class of proteins unresponsive to heat shock and are induced by glucose deprivation. Grp94 has been briefly studied as a prognostic factor in breast cancer.

Sorger, P.K. et al. J. Mol. Biol. 194: 341-344 (1987). | Tandon, A.K. et.al. Breast Cancer Res. and Treat. 16: 146 (1990). |

Additional Information

Conjugation

Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP

Size

50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type

Primary

Host species

Mouse

Reactivity (target)

Glucose Regulated Protein 94 (GRP94) (HSP90B1/1192)

Clonality

Monoclonal

Clone

HSP90B1/1192

Isotype

IgG1, kappa

Molecular weight

94 kDa

Synonyms
Entrez gene ID

7184

SwissProt

P14625

Immunogen

Recombinant full-length human HSP90B1 protein

Unigene

192374

Species reactivity

Human

Applications

Flow cytometry, Immunofluorescence, Immunohistology (formalin), Western

Cellular localization

Cytoplasmic and nuclear

Application notes

Flow Cytometry (0.5-1 ug/million cells/0.1 mL), Immunofluorescence 0.5-1.0 ug/mL, mmunohistology formalin-fixed 0.5-1.0 ug/mL for 30 minutes at RT, Optimal dilution for a specific application should be determined by user, Predicted to show broad species reactivity, Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes, Western blotting 0.5-1.0 ug/mL

Positive control

U20S cells. Breast Carcinoma

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

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