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Macrophage Specific Antigen Monoclonal Mouse Antibody (LN-5)

This MAb stains the cytoplasm of macrophages and histiocytes in hematopoietic organs, Kupffers cells of the liver and Langerhans cells of the skin.

Product Attributes

Antibody number

0059

Reactivity (target)

Macrophage Specific Antigen

Antibody type

Primary

Host species

Mouse

Clonality

Monoclonal

Clone

LN-5

Isotype

IgM, kappa

Molecular weight

Not Known

Synonyms

Not Known

Entrez gene ID

Not Known

SwissProt

Not Known

Unigene

Not Known

Immunogen

Human peripheral blood mononuclear cells

Cellular localization

Cytoplasmic

Species reactivity

Human

Applications

Immunofluorescence, Flow cytometry

Application notes

Immunofluorescence 0.5-1 ug/mL, Flow Cytometry 0.5-1 ug/million cells/0.1 mL

Positive control

Liver or histiocytoma

Shipping condition

Room temperature

Storage Conditions

Store at 2 to 8 °C, Note: store BSA-free antibodies at -10 to -35 °C

Shelf life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Regulatory status

For research use only (RUO)

Research areas

Immunology

Cell/tissue expression

Monocytes/macrophages

Conjugation
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Product Description

This MAb stains the cytoplasm of macrophages and histiocytes in hematopoietic organs, Kupffers cells of the liver and Langerhans cells of the skin. Macrophages comprise of many forms of mononuclear phagocytes found in tissues. Mononuclear phagocytes arise from hematopoietic stem cells in the bone marrow. After passing through the monoblast and pro-monocyte states of the monocyte stage, they enter the blood, where they circulate for about 40 hours. They then enter tissues and increase in size, phagocytic activity, and lysosomal enzyme content becoming macrophages. Among the functions of macrophages are nonspecific phagocytosis and pinocytosis, specific phagocytosis of opsonized microorganisms mediated by Fc receptors and complement receptors, killing of ingested microorganisms, digestion and presentation of antigens to T and B lymphocytes, and secretion of a large number of diverse products, including many enzymes including lysozyme and collagenases, several complement components and coagulation factors, some prostaglandins and leukotrienes, and many regulatory molecules (Interferon, Interleukin 1). LN-5 selectively stains human sebaceous glands in formalin-fixed, paraffin-embedded skin samples. Undifferentiated sebocyte progenitors are negative, and only sebocytes from the onset of their differentiation reveal positive cytoplasmic staining.

This antibody is available purified with BSA/azide at 200 ug/mL, or BSA/azide-free at 1 mg/mL.

References

Hsu SM et al. American Journal of Pathology. 138(6):1389-404 (1991).

Lis GJ, Litwin JA, Furgał-Borzych A, Pyka-Fościak G. Folia Histochem Cytobiol. 2012 Jul 5;50(2):319-21

 

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