Monoclonal anti PAX7 (PAX7/497)

BNUB0497-0
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Catalog #: BNUB0497
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Product Description

The Pax gene family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. In addition, the family is involved in a variety of signal transduction pathways in the adult organism. Mutations in the Pax family of proteins have been linked to disease and cancer in humans. Pax-7 is a protein specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization reveals that Pax-7 is also expressed in satellite cells residing in adult muscle. A chromosomal aberration in the gene encoding Pax-7 causes rhabdomyosarcoma 2 (RMS2) (also called alveolar rhabdomyosarcoma).

Additional Information

Conjugation

Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP

Size

50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type

Primary

Host species

Mouse

Reactivity (target)

PAX7 (PAX7/497)

Clonality

Monoclonal

Clone

PAX7/497

Isotype

IgG1, kappa

Molecular weight

57 kDa

Synonyms

HUP1; Paired box gene 7; Paired box homeotic gene 7; Paired domain gene HuP1; PAX7 transcriptional factor; PAX7/FKHR fusion gene; PAX7B; RMS2

Entrez gene ID

5081

SwissProt

P23759

Immunogen

Recombinant fragment (aa300-600) of human PAX7 protein

Unigene

113253

Species reactivity

Chicken, Human, Mouse, Rat, Zebrafish

Applications

Immunohistology (frozen)Western, Flow cytometry, Immunofluorescence

Cellular localization

Nuclear

Application notes

Flow Cytometry (0.5-1 ug/million cells/0.1 mL), Immunofluorescence 0.5-1 ug/mL, Immunohistology Frozen 0.5-1 ug/mL for 30 minutes at RT, Optimal dilution for a specific application should be determined by user, Western blotting 0.5-1 ug/mL

Positive control

HeLa, Jurkat, A431, MCF-7, U2OS or NIH/3T3 cells. Rhabdomyosarcoma (RMS)

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

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